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Open Access 01-12-2014 | Review

Mechanisms of hypothermia-induced cell protection in the brain

Authors: Katharina Rose Luise Schmitt, Giang Tong, Felix Berger

Published in: Molecular and Cellular Pediatrics | Issue 1/2014

Abstract

Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention.

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Title: Mechanisms of hypothermia-induced cell protection in the brain
Authors: Katharina Rose Luise Schmitt
Giang Tong
Felix Berger
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2014
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-014-0007-x

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