Skip to main content
Top
Published in: Molecular and Cellular Pediatrics 1/2014

Open Access 01-12-2014 | Mini review

Perinatal programming - myths, fact, and future of research

Author: Jörg Dötsch

Published in: Molecular and Cellular Pediatrics | Issue 1/2014

Login to get access

Abstract

Background and Findings

Perinatal programming, i.e., the (epigenetic) modification of (genetic) functions throughout lifetime, suffers from the notion of premature theories and difficult and extensive research strategies.

Conclusions

This mini review aims at depicting 9 current developments and discusses possible future research strategies.
Appendix
Available only for authorised users
Literature
1.
go back to reference Hales CN, Barker DJ: The thrifty phenotype hypothesis. Br Med Bull 2001, 60: 5–20. 10.1093/bmb/60.1.5CrossRef Hales CN, Barker DJ: The thrifty phenotype hypothesis. Br Med Bull 2001, 60: 5–20. 10.1093/bmb/60.1.5CrossRef
2.
go back to reference Hales CN, Barker DJ: Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992, 35(7):595–601. 10.1007/BF00400248CrossRef Hales CN, Barker DJ: Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992, 35(7):595–601. 10.1007/BF00400248CrossRef
3.
go back to reference Dötsch J, Plank C, Amann K: Fetal programming of renal function. Pediatr Nephrol 2012, 27(4):513–520. doi:10.1007/s00467–011–1781–5 10.1007/s00467-011-1781-5CrossRef Dötsch J, Plank C, Amann K: Fetal programming of renal function. Pediatr Nephrol 2012, 27(4):513–520. doi:10.1007/s00467–011–1781–5 10.1007/s00467-011-1781-5CrossRef
4.
go back to reference Rother E, Kuschewski R, Alcazar MA, Oberthuer A, Bae-Gartz I, Vohlen C, Roth B, Dötsch J: Hypothalamic JNK1 and IKKβ activation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding. Endocrinology 2012, 153(2):770–781. doi:10.1210/en.2011–1589. Epub 2011 Dec 6 10.1210/en.2011-1589CrossRef Rother E, Kuschewski R, Alcazar MA, Oberthuer A, Bae-Gartz I, Vohlen C, Roth B, Dötsch J: Hypothalamic JNK1 and IKKβ activation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding. Endocrinology 2012, 153(2):770–781. doi:10.1210/en.2011–1589. Epub 2011 Dec 6 10.1210/en.2011-1589CrossRef
5.
go back to reference Gluckman PD, Hanson MA, Cooper C, Thornburg KL: Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008, 359: 61–73. 10.1056/NEJMra0708473CrossRef Gluckman PD, Hanson MA, Cooper C, Thornburg KL: Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008, 359: 61–73. 10.1056/NEJMra0708473CrossRef
6.
go back to reference Plagemann A: Toward a unifying concept on perinatal programming: vagetative imprinting b environment-dependent biocybernetogenesis. In Plagemann A. Peinatal programming. The State of Art. De Gruyter, Berlin/Boston; 2012:243–282. Plagemann A: Toward a unifying concept on perinatal programming: vagetative imprinting b environment-dependent biocybernetogenesis. In Plagemann A. Peinatal programming. The State of Art. De Gruyter, Berlin/Boston; 2012:243–282.
7.
go back to reference Hogg K, Price EM, Hanna CW, Robinson WP: Prenatal and perinatal environmental influences on the human fetal and placental epigenome. Clin Pharmacol Ther 2012, 92(6):716–726. doi:10.1038/clpt.2012.141. Epub 2012 Oct 10. Review 10.1038/clpt.2012.141CrossRef Hogg K, Price EM, Hanna CW, Robinson WP: Prenatal and perinatal environmental influences on the human fetal and placental epigenome. Clin Pharmacol Ther 2012, 92(6):716–726. doi:10.1038/clpt.2012.141. Epub 2012 Oct 10. Review 10.1038/clpt.2012.141CrossRef
8.
go back to reference Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE, Heijmans BT: DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009, 18(21):4046–4053. doi:10.1093/hmg/ddp353. Epub 2009 Aug 4 10.1093/hmg/ddp353CrossRef Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE, Heijmans BT: DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009, 18(21):4046–4053. doi:10.1093/hmg/ddp353. Epub 2009 Aug 4 10.1093/hmg/ddp353CrossRef
9.
go back to reference Tobi EW, Slagboom PE, van Dongen J, Kremer D, Stein AD, Putter H, Heijmans BT, Lumey LH: Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19. PLoS One 2012, 7(5):e37933. doi:10.1371/journal.pone.0037933. Epub 2012 May 30 10.1371/journal.pone.0037933CrossRef Tobi EW, Slagboom PE, van Dongen J, Kremer D, Stein AD, Putter H, Heijmans BT, Lumey LH: Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19. PLoS One 2012, 7(5):e37933. doi:10.1371/journal.pone.0037933. Epub 2012 May 30 10.1371/journal.pone.0037933CrossRef
10.
go back to reference Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR, Emerald BS, Gale CR, Inskip HM, Cooper C, Hanson MA: Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes 2011, 60(5):1528–1534. doi:10.2337/db10–0979. Epub 2011 Apr 6 10.2337/db10-0979CrossRef Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR, Emerald BS, Gale CR, Inskip HM, Cooper C, Hanson MA: Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes 2011, 60(5):1528–1534. doi:10.2337/db10–0979. Epub 2011 Apr 6 10.2337/db10-0979CrossRef
11.
go back to reference Keller G, Zimmer G, Mall G, Ritz E, Amann K: Nephron number in patients with primary hypertension. N Engl J Med 2003, 348(2):101–108. 10.1056/NEJMoa020549CrossRef Keller G, Zimmer G, Mall G, Ritz E, Amann K: Nephron number in patients with primary hypertension. N Engl J Med 2003, 348(2):101–108. 10.1056/NEJMoa020549CrossRef
12.
go back to reference Lucassen PJ, Naninck EF, van Goudoever JB, Fitzsimons C, Joels M, Korosi A: Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Trends Neurosci 2013, 36(11):621–631. doi:10.1016/j.tins.2013.08.002. Epub 2013 Aug 30 10.1016/j.tins.2013.08.002CrossRef Lucassen PJ, Naninck EF, van Goudoever JB, Fitzsimons C, Joels M, Korosi A: Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Trends Neurosci 2013, 36(11):621–631. doi:10.1016/j.tins.2013.08.002. Epub 2013 Aug 30 10.1016/j.tins.2013.08.002CrossRef
13.
go back to reference Bouret SG, Draper SJ, Simerly RB: Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004, 304(5667):108–110. 10.1126/science.1095004CrossRef Bouret SG, Draper SJ, Simerly RB: Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004, 304(5667):108–110. 10.1126/science.1095004CrossRef
14.
go back to reference Murgatroyd C, Spengler D: Epigenetic programming of the HPA axis: early life decides. Stress 2011, 14(6):581–589. doi: 10.3109/10253890.2011.602146. Epub 2011 Aug 19. ReviewCrossRef Murgatroyd C, Spengler D: Epigenetic programming of the HPA axis: early life decides. Stress 2011, 14(6):581–589. doi: 10.3109/10253890.2011.602146. Epub 2011 Aug 19. ReviewCrossRef
15.
go back to reference Vikse BE, Irgens LM, Leivestad T, Hallan S, Iversen BM: Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 2008, 19(1):151–157. Epub 2007 Dec 5 10.1681/ASN.2007020252CrossRef Vikse BE, Irgens LM, Leivestad T, Hallan S, Iversen BM: Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 2008, 19(1):151–157. Epub 2007 Dec 5 10.1681/ASN.2007020252CrossRef
16.
go back to reference Nüsken KD, Schneider H, Plank C, Trollmann R, Nüsken E, Rascher W, DÖtsch J: Fetal programming of gene expression in growth-restricted rats depends on the cause of low birth weight. Endocrinology 2011, 152(4):1327–1335. doi:10.1210/en.2010–1116. Epub 2011 Jan 25 10.1210/en.2010-1116CrossRef Nüsken KD, Schneider H, Plank C, Trollmann R, Nüsken E, Rascher W, DÖtsch J: Fetal programming of gene expression in growth-restricted rats depends on the cause of low birth weight. Endocrinology 2011, 152(4):1327–1335. doi:10.1210/en.2010–1116. Epub 2011 Jan 25 10.1210/en.2010-1116CrossRef
17.
go back to reference Bouchard L: Epigenetics and fetal metabolic programming: a call for integrated research on larger cohorts. Diabetes 2013, 62(4):1026–1028. doi:10.2337/db12–1763 10.2337/db12-1763CrossRef Bouchard L: Epigenetics and fetal metabolic programming: a call for integrated research on larger cohorts. Diabetes 2013, 62(4):1026–1028. doi:10.2337/db12–1763 10.2337/db12-1763CrossRef
18.
go back to reference Ruchat SM, Hivert MF, Bouchard L: Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus. Nutr Rev 2013, 71(Suppl 1):S88-S94. doi:10.1111/nure.12057 10.1111/nure.12057CrossRef Ruchat SM, Hivert MF, Bouchard L: Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus. Nutr Rev 2013, 71(Suppl 1):S88-S94. doi:10.1111/nure.12057 10.1111/nure.12057CrossRef
19.
go back to reference Guttmacher AE, Hirschfeld S, Collins FS: The National Children's Study - a proposed plan. N Engl J Med 2013, 369(20):1873–1875. doi:10.1056/NEJMp1311150 10.1056/NEJMp1311150CrossRef Guttmacher AE, Hirschfeld S, Collins FS: The National Children's Study - a proposed plan. N Engl J Med 2013, 369(20):1873–1875. doi:10.1056/NEJMp1311150 10.1056/NEJMp1311150CrossRef
20.
go back to reference Rabadán-Diehl C, Nathanielsz P: From mice to men: research models of developmental programming. J Dev Orig Health Dis 2013, 4(1):3–9. 10.1017/S2040174412000487CrossRef Rabadán-Diehl C, Nathanielsz P: From mice to men: research models of developmental programming. J Dev Orig Health Dis 2013, 4(1):3–9. 10.1017/S2040174412000487CrossRef
Metadata
Title
Perinatal programming - myths, fact, and future of research
Author
Jörg Dötsch
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Molecular and Cellular Pediatrics / Issue 1/2014
Electronic ISSN: 2194-7791
DOI
https://doi.org/10.1186/s40348-014-0002-2

Other articles of this Issue 1/2014

Molecular and Cellular Pediatrics 1/2014 Go to the issue