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01-12-2021 | Magnetic Resonance Imaging | Protocol

Use of magnetic resonance imaging-guided radiotherapy for breast cancer: a scoping review protocol

Authors: Sarah Elliott, Alexandra Berlangieri, Jason Wasiak, Michael Chao, Farshad Foroudi

Published in: Systematic Reviews | Issue 1/2021

Abstract

Background

In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated with this advanced technology impact immediate widespread use and availability. There are currently limited studies to demonstrate the clinical effectiveness and inform decision-making on the use of MRI in radiotherapy. The objective of this scoping review is to identify and map the existing evidence surrounding the clinical implementation of MRI-guided radiotherapy in patients with breast cancer. It also aims to identify challenges and knowledge gaps in the literature.

Methods

We will perform a comprehensive search in MEDLINE and EMBASE databases from January 2010 onwards. Grey literature sources will include the WHO International Clinical Trials Registry Platform. We will include systematic reviews, randomised and non-randomised controlled studies published in English. Literature should examine the use of magnetic resonance imaging-guided radiotherapy in adults with breast cancer, regardless of cancer stage or severity. Two reviewers will independently screen all titles, abstracts and full-text reports. Data will be extracted and summarised using qualitative (e.g. content and thematic analysis) methods and presented in tables.

Discussion

The results from this review will consolidate the evidence surrounding MRI-guided radiotherapy for breast cancer, contributing to the development and optimisation of patient selection, simulation, planning, treatment delivery, quality assurance and research, to help improve patient outcomes, cancer care and treatment for women with breast cancer.

Systematic review registration

The protocol is available on Open Science Framework at DOI https://doi.org/10.17605/OSF.IO/8TEV6

Available only for authorised users

World Health Organization statistics. https://www.who.int/cancer/prevention/diagnosis-screening/breast-cancer/en/ Accessed 10 June 2020

National Cancer Control Indicators. Distribution of cancer stage; published 26 Apr, 2018: or https://ncci.canceraustralia.gov.au/diagnosis/distribution-cancer-stage/distribution-cancer-stage Accessed 10 June 2020

Heilat GB, Brennan ME, French J. Update on the management of early-stage breast cancer. AJGP. 2019;48(9):604-608. doi:10.31128/AJGP-03-19-4891

Whelan TJ, Pignol JP, Levine MN, et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med. 2010;362(6):513–20. https://doi.org/10.1056/NEJMoa0906260.CrossRefPubMed

Brunt AM, Haviland JS, Wheatley DA el al. Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial. Lancet. 2020;395:1613-26. doi:10.1016/S0140-6736(20)30932-6

Strand V, Ott OJ, Hildebrandt G, et al. 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial. Lancet. 2016;387:229–38. https://doi.org/10.1016/S0140-6736(15)00471-7.CrossRef

Vaidya JS, Joseph DJ, Tobias JS et al, Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet. 2010;376:91-102. doi:10.1016/S0140- 6736(10)60837-9

Veronesi U, Orechhia R, Masionneuve P, et al. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol. 2013;14:1269–77. https://doi.org/10.1016/S1470-2045(13)70497-2.CrossRefPubMed

Vicini FA, Cecchini RS, White JR, et al. Primary results of NSABP B39/RTOG 0413 (NRG Oncology): A randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I, or II breast cancer. Cancer Research. 2019;79 Suppl 4. doi:10.1158/1538-7445.SABCS18-GS4-04

10.

Whelan T, Julian J, Levine M et al. RAPID: a randomized trial of accelerated partial breast irradiation using 3-dimensional conformal radiotherapy (3D-CRT). Cancer Research. 2019;79 Suppl 4. doi:10.1158/1538-7445.SABCS18-GS4-03

11.

Polgar C, Limbergen EV, Potter R, et al. Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe European de Curietherapie-European Society for Therapeutic Radiology and Oncology (GEC_ESTRO) breast cancer working group based on clinical evidence (2009). Radiother Oncology. 2010;94(3):264–73. https://doi.org/10.1016/j.radonc.2010.01.014.CrossRef

12.

Smith BD, Arthur DW, Buchholz TA, et al. Accelerated Partial Breast Irradiation Consensus Statement From the American Society for Radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys. 2009;74(4):987–1001. https://doi.org/10.1016/j.ijrobp.2009.02.031.CrossRefPubMed

13.

Van Mourik AM, Elkhuizen PHM, Minkema D, et al. Multiinstitutional study on target volume delineation variation in breast radiotherapy in the presence of guidelines. Radiother Oncol. 2010;94(3):286–91. https://doi.org/10.1016/j.radonc.2010.01.009.CrossRefPubMed

14.

Landis D, Luo W, Song J, et al. Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity. IJROBP. 2007;67(5):1299–308. https://doi.org/10.1016/j.ijrobp.2006.11.026.CrossRef

15.

Struikmans H, Warlam-Rodenjuis C, Stam T, et al. Interobserver variability of clinical target volume delineation of glandular breast tissue and of boost volume in tangential breast irradiation. Radiother Oncol. 2005;76(3):293–9. https://doi.org/10.1016/j.radonc.2005.03.029.CrossRefPubMed

16.

Boersma LJ, Janssen T, Elkjuizen PHM, et al. Reducing interobserver variation of boost-CTV delineation in breast conserving radiation therapy using a pre-operative CT and delineation guidelines. Radiother Oncol. 2012;103(2):178–82. 20.1016/jradonc.2011.12.021.CrossRefPubMed

17.

Schmitz AC, van den Bosch MAAJ, Loo CE, et al. Precise correlation between MRI and histopathology – Exploring treatment margins for MRI-guided localized breast cancer therapy. Radiother Oncol. 2010;97(2):225–32. https://doi.org/10.1016/j.radonc.2010.07.025.CrossRefPubMed

18.

Schmitz AC, Pengel KE, Loo CE, et al. Pre-treatment imaging and pathology characteristics of invasive breast cancers of limited extent: Potential relevance for MRI-guided localized therapy. Radiother Oncol. 2012;104:11–8. https://doi.org/10.1016/jradonc.2012.01.014.CrossRefPubMed

19.

Den Hartogh MD, Philippens MEP, Van Dam IE et al. MRI and CT imaging for preoperative target volume delineation breast-conserving therapy. Radiation Oncology. 2014;9:63-717X-9-63

20.

Di Leo G, Trimboli RM, Benedek A, et al. MR imaging for selection of patients for partial breast irradiation: A systematic review and meta-analysis. Radiology. 2015;277(3):716–26.CrossRefPubMed

21.

Charaghvandi RK, den Hartogh MD, van Ommen AMLN, et al. MRI-guided single fraction ablative radiotherapy for early-stage breast cancer: a brachytherapy versus volumetric modulated arc therapy dosimetry study. Radiother Oncol. 2015;117(3):477–82. https://doi.org/10.1016/jradonc.2015.09.023.CrossRefPubMed

22.

Metcalfe P, Liney GP, Holloway L et al. The potential for an enhanced role for MRI in radiation-therapy treatment planning. Technology in Cancer Research and Treatment. 2013;12(5):429-446. doi:10.77885/tcrt.2012.500342

23.

Arivarasan H, Anuradha C, Subramanian S, et al. Magnetic resonance iage guidance in external beam radiation therapy planning and delivery. Jpn J Radiol. 2017;35:417–26. https://doi.org/10.1007/s11604-017-0656-5.CrossRefPubMed

24.

Lagendijk JJW, Raaymakers BW, van Vulpen M. The magnetic resonance imaging-linac system. Semin Radiat Oncol. 2014;24:207–9. https://doi.org/10.1016/j.semradonc.2014.02.009.CrossRefPubMed

25.

Corradini S, Alongi F, Andratschke N, et al. MR-guidance in clinical reality: current treatment challenges and future perspectives. Radiat Oncol. 2019;14:92.CrossRefPubMedPubMedCentral

26.

Henke LE, Contreras JA, Green OK et al. Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A 4.5-year clinical experience. Clinical Oncology. 2018;30:720-727. doi:10.1016/j.clon.2018.08.010

27.

van Heijst TC, den Hartogh MD, Lagendijk JJ, et al. MR-guided breast radiotherapy: feasibility and magnetic-field impact on skin dose. Phys Med Biol. 2013;58(17):5917–30. https://doi.org/10.1088/0031-9155/58/17/5917.CrossRefPubMed

28.

Kim A, Lim-Reinders S, McCann C, et al. Magnetic field dose effects on different radiation beam geometries for hypofractionated partial breast irradiation. J Appl Clin Med Phys. 2017;18(6):62–70. https://doi.org/10.1002/acm2/12182.CrossRefPubMedCentralPubMed

29.

Park JM, Shin KH, J-i K, et al. Air–electron stream interactions during magnetic resonance IGRT. Strahlentherapie und Onkologie. 2018;194(1):50–9. https://doi.org/10.1007/s00066-017-1212-z.CrossRefPubMed

30.

Han EY, Wen Z, Lee HJ, et al. Measurement of electron return effect and skin dose reduction by a bolus in an anthropomorphic physical phantom under a magnetic resonance guided linear accelerator (MR-LINAC) system. Int J Med Phys Clin Eng Rad Oncol. 2018;7:339–46. https://doi.org/10.4236/ijmpcero.2018.73028.CrossRef

31.

Nachbar M, Mönnich D, Boeke S, et al. Partial breast irradiation with the 1.5 T MR-Linac: First patient treatment and analysis of electron return and stream effects. Radiotherapy and Oncology. 2020;145:30–5. https://doi.org/10.1016/j.radonc.2019.11.025.CrossRefPubMed

32.

Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and met-analysis (PRISMA-P) 2015 statement. Syst. Rev. 2014;4(1):1. https://doi.org/10.1186/2046-4053-4-1.CrossRef

33.

Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;350:g7647. https://doi.org/10.1136/bmj.g7647.CrossRefPubMed

34.

Tricco AC, Lilli E, Zarin W, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467–73. https://doi.org/10.7326/M18-0850.CrossRefPubMed

35.

Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;8(1):19–32. https://doi.org/10.1080/1364557032000119616.CrossRef

36.

Levac D, Colquhoun H, O’Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69. https://doi.org/10.1186/1748-5908-5-69.CrossRefPubMedCentralPubMed

37.

Covidence systematic review software, Veritas Health Innovation, Melbourne, Australia; 2013. Available at www.covidence.org Accessed 03 June 2020

Title: Use of magnetic resonance imaging-guided radiotherapy for breast cancer: a scoping review protocol
Authors: Sarah Elliott
Alexandra Berlangieri
Jason Wasiak
Michael Chao
Farshad Foroudi
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Breast Cancer
Breast Cancer
Radiotherapy
Published in: Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-021-01594-9

At a glance: The STEP trials

Springer Medicine

Use of magnetic resonance imaging-guided radiotherapy for breast cancer: a scoping review protocol

Abstract

Background

Methods

Discussion

Systematic review registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Discussion

Systematic review registration

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