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Systematic Reviews
Published in: Systematic Reviews 1/2021

Open Access 01-12-2021 | Malaria | Systematic review update

Endectocides as a complementary intervention in the malaria control program: a systematic review

Authors: Fereshteh Ghahvechi Khaligh, Abbas Jafari, Elena Silivanova, Mikhail Levchenko, Bahlol Rahimi, Saber Gholizadeh

Published in: Systematic Reviews | Issue 1/2021

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Abstract

Background

Malaria is the most common vector-borne disease transmitted to humans by Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be valuable for trial design and clinical studies to control malaria transmission.

Methods

PubMed/MEDLINE, Scopus, Web of Science, and Science Direct were searched for original English published papers on (“Malaria chemical control” OR “Malaria elimination” OR “Anopheles vector control” OR “Malaria zooprophylaxis”) AND (“Systemic insecticides” OR “Endectocides” OR “Ivermectin”). The last search was from 19 June 2019 to 31 December 2019. It was updated on 17 November 2020. Two reviewers (SG and FGK) independently reviewed abstracts and full-text articles. Data were extracted by one person and checked by another. As meta-analyses were not possible, a qualitative summary of results was performed.

Results

Thirty-six published papers have used systemic insecticides/endectocides for mosquito control. Most of the studies (56.75%) were done on Anopheles gambiae complex species on doses from 150 μg/kg to 400 μg/kg in several studies. Target hosts for employing systemic insecticides/drugs were animals (44.2%, including rabbit, cattle, pig, and livestock) and humans (32.35%).

Conclusions

Laboratory and field studies have highlighted the potential of endectocides in malaria control. Ivermectin and other endectocides could soon serve as novel malaria transmission control tools by reducing the longevity of Anopheles mosquitoes that feed on treated hosts, potentially decreasing Plasmodium parasite transmission when used as mass drug administration (MDA).
Appendix
Available only for authorised users
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Metadata
Title
Endectocides as a complementary intervention in the malaria control program: a systematic review
Authors
Fereshteh Ghahvechi Khaligh
Abbas Jafari
Elena Silivanova
Mikhail Levchenko
Bahlol Rahimi
Saber Gholizadeh
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-021-01578-9

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