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01-12-2021 | Alzheimer's Disease | Protocol

Exercise interventions for older adults with Alzheimer’s disease: a systematic review and meta-analysis protocol

Authors: Julie M. Faieta, Hannes Devos, Prasanna Vaduvathiriyan, Michele K. York, Kirk I. Erickson, Mark A. Hirsch, Brian G. Downer, Erwin E. H. van Wegen, Diana C. Wong, Elena Philippou, Ahmed Negm, Pedram Ahmadnezhad, Shilpa Krishnan, Melike Kahya, Pallavi Sood, Patricia C. Heyn

Published in: Systematic Reviews | Issue 1/2021

Abstract

Background

The growing societal and economic impact of Alzheimer’s disease (AD) is further compounded by the present lack of disease-modifying interventions. Non-pharmacological intervention approaches, such as exercise, have the potential to be powerful approaches to improve or mitigate the symptoms of AD without added side effects or financial burden associated with drug therapies. Various forms and regiments of exercise (i.e., strength, aerobic, multicomponent) have been reported in the literature; however, conflicting evidence obscures clear interpretation of the value and impact of exercise as an intervention for older adults with AD. The primary objective of this review will be to evaluate the effects of exercise interventions for older adults with AD. In addition, this review will evaluate the evidence quality and synthesize the exercise training prescriptions for proper clinical practice guidelines and recommendations.

Methods

This systematic review and meta-analysis will be carried out by an interdisciplinary collective representing clinical and research stakeholders with diverse expertise related to neurodegenerative diseases and rehabilitation medicine. Literature sources will include the following: Embase, PsychINFO, OVID Medline, and Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily. Inclusion criteria are participants with late onset AD and structured exercise interventions with prescribed duration, frequency, and intensity. The primary outcome of this study will center on improved or sustained cognitive functioning. Secondary outcomes will include institutionalization-related outcomes, ability in activities of daily living, mood and emotional well-being, quality of life, morbidity, and mortality. Analysis procedures to include measurement of bias, data synthesis, sensitivity analysis, and assessment of heterogeneity are described in this protocol.

Discussion

This review is anticipated to yield clinically meaningful insight on the specific value of exercise for older adults with AD. Improved understanding of diverse exercise intervention approaches and their specific impact on various health- and function-related outcomes is expected to guide clinicians to more frequently and accurately prescribe meaningful interventions for those affected by AD.

Systematic review registration

PROSPERO CRD42020175016.

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Title: Exercise interventions for older adults with Alzheimer’s disease: a systematic review and meta-analysis protocol
Authors: Julie M. Faieta
Hannes Devos
Prasanna Vaduvathiriyan
Michele K. York
Kirk I. Erickson
Mark A. Hirsch
Brian G. Downer
Erwin E. H. van Wegen
Diana C. Wong
Elena Philippou
Ahmed Negm
Pedram Ahmadnezhad
Shilpa Krishnan
Melike Kahya
Pallavi Sood
Patricia C. Heyn
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Alzheimer's Disease
Dementia
Alzheimer's Disease
Dementia
Published in: Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-020-01555-8

At a glance: The STEP trials

Springer Medicine

Exercise interventions for older adults with Alzheimer’s disease: a systematic review and meta-analysis protocol

Abstract

Background

Methods

Discussion

Systematic review registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Discussion

Systematic review registration

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