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Systematic Reviews
Published in: Systematic Reviews 1/2017

Open Access 01-12-2017 | Protocol

Paraquat and Parkinson’s disease: a systematic review protocol according to the OHAT approach for hazard identification

Authors: Carolina Vaccari, Regina El Dib, João Lauro V. de Camargo

Published in: Systematic Reviews | Issue 1/2017

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Abstract

Background

Parkinson’s disease (PD) is a progressive neurodegenerative condition that has genetic susceptibility, aging, and exposure to certain chemicals as risk factors. In recent decades, epidemiological and experimental studies have investigated the role of pesticides in the development of PD, in particular that of the herbicide paraquat. Here, we, therefore, aim to systematically review the association between paraquat exposure and PD.

Methods

Observational studies (cohort, case–control, and cross-sectional) eligible for this systematic review will enroll any participant who was occupationally and/or environmentally exposed to paraquat. Experimental studies, including in vivo and in vitro assays designed to assess neurotoxicological endpoints or mechanisms of paraquat neurotoxicity, will also be eligible. Outcomes of interest include the following: PD diagnosis; neurobehavioral, biochemical, and/or morphological alterations; and cellular, biochemical, and/or molecular pathways to oxidative stress. Using terms to include all forms of paraquat combined with PD, the following electronic databases will be searched: PubMed, EMBASE, LILACS, Toxnet, and Web of Science, without restrictions as to language, year, or status of publication. A team of reviewers will independently select potential titles and abstracts, extract data, assess risk of bias, and determine the overall quality of evidence for each outcome using the Office of Health Assessment and Translation (OHAT) approach for systematic reviews and evidence integration. Dichotomous data will be summarized as odds ratios, and continuous data will be given as mean differences, both with their respective 95% confidence intervals.

Discussion

This is the first time that the OHAT systematic review protocol will be applied to investigate a possible causal association between exposure to paraquat and PD. Results from this study could serve as basis for regulatory agencies to define paraquat levels of concern, supporting its risk assessment process.

Systematic review registration

PROSPERO CRD42016050861
Appendix
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Literature
1.
Greenamyre JT, MacKenzie G, Peng T, Stephans SE. Mitochondrial dysfunction in Parkinson’s disease. Biochem Soc Symp. 1999;66:85–97.CrossRefPubMed
2.
3.
Ebadi M, Sharma SK. Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson’s disease. Antioxid Redox Signal. 2003;5:319–35.CrossRefPubMed
4.
McNaught KS, Olanow CW. Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson’s disease. Ann Neurol. 2003;53 suppl 3:S73–84.CrossRefPubMed
5.
Alves DC. Recent advances on a-synuclein cell biology: functions and dysfunctions. Curr Mol Med. 2003;3:17–24.CrossRef
6.
Di Monte DA, Lavasani M, Manning-Bog AB. Environmental factors in Parkinson’s disease. Neurotoxicology. 2002;23:487–502.CrossRefPubMed
7.
Warner TT, Schapira AH. Genetic and environmental factors in the cause of Parkinson’s disease. Ann Neurol. 2003;53:16–25.CrossRef
8.
Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Sci Transl Med. 1983;219:979–80.
9.
He XJ, Uchida K, Megumi C, Tsuge N, Nakayama H. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. J Toxicol Pathol. 2015;28:197–206.CrossRefPubMedPubMedCentral
10.
Jing H, Wang S, Wang M, Fu W, Zhang C, Xu D. Isobavachalcone attenuates MPTP-induced Parkinson’s disease in mice by inhibition of microglial activation through NF-κB pathway. PLoS One. 2017;12:e0169560.CrossRefPubMedPubMedCentral
11.
Elgueta D, Aymerich MS, Contreras F, Montoya A, Celorrio M, Rojo-Bustamante E, et al. Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson’s disease. Neuropharmacology. 2017;113:110–23.CrossRefPubMed
12.
Fei Q, McCormack AL, Di Monte DA, Ethell DW. Paraquat neurotoxicity is mediated by a Bak-dependent mechanism. J Biol Chem. 2002;283:3357–64.CrossRef
13.
Richardson JR. Paraquat neurotoxicity is distinct from that of MPTP and rotenone. Toxicol Sci. 2005;88:193–201.CrossRefPubMed
14.
Yang W, Chen L, Ding Y, Zhuang X, Kang UJ. Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Hum Mol Genet. 2007;16:2900–10.CrossRefPubMed
15.
Morán JM, Gonzalez-Polo RA, Ortiz-Ortiz MA, Niso-Santano M, Soler G, Fuentes JM. Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways. J Toxicol Environ Health A. 2008;71:1457–67.CrossRefPubMed
16.
Yang W, Tiffany-Castiglioni E, Koh HC, Sona IH. Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Toxicol Lett. 2009;191:203–10.CrossRefPubMed
17.
18.
Esfahani M. Effects of pre-harvest application of paraquat on grain moisture reduction, grain yield and quality of rapeseed (Brassica napus L.) cultivars. Caspian J Environ Sci. 2012;10:75–82.
19.
20.
Kuter K, Smiałowska M, Wieronska J, Zieba B, Wardas J, Pietraszek M, et al. Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats. Brain Res. 2007;1155:196–207.CrossRefPubMed
21.
Kuter K, Nowak P, Golembiowska K, Ossowska K. Increased reactive oxygen species production in the brain after repeated low-dose pesticide paraquat exposure in rats: a comparison with peripheral tissues. Neurochem Res. 2010;35:1121–30.CrossRefPubMed
22.
Liou HH, Chen RC, Tsai YF, Chen WP, Chang YC, Tsai MC. Effects of paraquat on the substantia nigra of the Wistar rats: neurochemical, histological, and behavioral studies. Toxicol Appl Pharmacol. 1996;137:34–41.CrossRefPubMed
23.
Le Couteur DG, Mc Lean AJ, Taylor MC, Woodham BL, Board PG. Pesticides and Parkinson’s disease. Biomed Pharmacother. 1999;53:122–30.CrossRefPubMed
24.
Kamel F, Tanner C, Umbach D, Hoppin JA, Alavanja MCR, Blair A, et al. Pesticide exposure and self-reported Parkinson’s disease in the agricultural health study. Am J Epidemiol. 2006;165:364–74.CrossRefPubMed
25.
Dick FD, De Palma G, Ahmadi A, Scott NW, Prescott GJ, Bennett J, et al. Environmental risk factors for Parkinson’s disease and parkinsonism: the Geoparkinson study. Occup Environ Med. 2007;64:666–72.CrossRefPubMedPubMedCentral
26.
Berry C, La Vecchia C, Nicotera P. Paraquat and Parkinson’s disease. Cell Death Differ. 2010;17:1115–25.CrossRefPubMed
27.
28.
Adami HO, Berry SCL, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D, et al. Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference. Toxicol Sci. 2011;122:223–34.CrossRefPubMedPubMedCentral
29.
Priyadarshi A, Khuder SA, Schaub EA, Shrivastava S. A meta-analysis of Parkinson’s disease and exposure to pesticides. Neurotoxicology. 2000;21:435–40.PubMed
30.
Priyadarshi A, Khuder SA, Schaub EA, Priyardarshi SS. Environmental risk factors and Parkinson’s disease: a metaanalysis. Environ Res. 2001;86:122–7.CrossRefPubMed
31.
Van der Mark M, Brower M, Kromhout H, Nijssen P, Huss A, Vermeulen R. Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results. Environ Health Perspect. 2011;120:340–7.CrossRefPubMedCentral
32.
Freire C, Koifman S. Pesticide exposure and Parkinson’s disease: epidemiological evidence of association. Neurotoxicology. 2012;33:947–71.CrossRefPubMed
33.
Li AA, Mink PJ, McIntosh LJ, Teta MJ, Finley B. Evaluation of epidemiologic and animal data associating pesticides with Parkinson’s disease. J Occup Environ Med. 2005;47:1059–87.CrossRefPubMed
34.
Brown TP, Rumsby PC, Capleton AC, Rushton L, Levy LS. Pesticides and Parkinson’s disease—Is there a link? Environ Health Perspect. 2006;114:156–64.CrossRefPubMed
35.
Van Maele-Fabry G, Hoet P, Vilain F, Lison D. Occupational exposure to pesticides and Parkinson’s disease: a systematic review and meta-analysis of cohort studies. Environ Int. 2012;46:30–43.CrossRefPubMed
36.
Allen MT, Levy LS. Parkinson’s disease and pesticide exposure—a new assessment. Crit Rev Toxicol. 2013;43:515–34.CrossRefPubMed
37.
Pezzoli G, Cereda E. Exposure to pesticides or solvents and risk of Parkinson disease. Neurology. 2013;80:2035–41.CrossRefPubMed
38.
39.
Breckenridge CB, Berry C, Chang ET, Sielken RL, Mandel JS. Association between Parkinson’s disease and cigarette smoking, rural living, well-water consumption, farming and pesticide use: systematic review and meta-analysis. PLoS ONE. 2016;11:e0151841.CrossRefPubMedPubMedCentral
40.
41.
42.
43.
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A (deceased), Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMAP) 2015: elaboration and explanation. BMJ. 2015;2:g7647.
44.
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000;283:2008–12.CrossRefPubMed
45.
46.
Higgins JPT, Altman DG, Sterne JAC. Assessing risk of bias in included studies. In: Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011. http://​handbook.​cochrane.​org/​. Accessed 11 Nov 2016.
47.
48.
49.
Vesterinen HM, Sena ES, Egan KJ, Hirst TC, Churolov L, Currie GL, et al. Meta-analysis of data from animal studies: a practical guide. J Neurosci Methods. 2014;221:92–102.CrossRefPubMed
50.
Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol. 2001;54:1046–55.CrossRefPubMed
51.
52.
El Dib R, Gomaa H, Carvalho RP, Camargo SE, Bazan R, Barretti P, et al. Enzyme replacement therapy for Anderson-Fabry disease. Cochrane Database Syst Rev. 2016;7:CD006663.PubMed
53.
McGuinness MB, Karahalios A, Finger RP, Guymer RH, Simpson JA. Age-related macular degeneration and mortality: a systematic review and meta-analysis. Ophthalmic Epidemiol. 2017;24:141–52.
54.
Wang Z, Xiao L, Guo H, Zhao G, Ma J. The efficiency and safety of fibrin sealant for reducing blood loss in primary total hip arthroplasty: a systematic review and meta-analysis. Int J Surg. 2017;37:50–7.CrossRefPubMed
Metadata
Title
Paraquat and Parkinson’s disease: a systematic review protocol according to the OHAT approach for hazard identification
Authors
Carolina Vaccari
Regina El Dib
João Lauro V. de Camargo
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2017
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-017-0491-x

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