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Open Access 01-12-2016 | Protocol

Measurement properties of quality of life measurement instruments for infants, children and adolescents with eczema: protocol for a systematic review

Authors: Daniel Heinl, Cecilia A. C. Prinsen, Aaron M. Drucker, Robert Ofenloch, Rosemary Humphreys, Tracey Sach, Carsten Flohr, Christian Apfelbacher

Published in: Systematic Reviews | Issue 1/2016

Abstract

Background

Eczema is a common chronic or chronically relapsing, inflammatory skin disease that exerts a substantial negative impact on quality of life (QoL). The Harmonising Outcome Measures for Eczema (HOME) initiative has used a consensus-based process which identified QoL as one of the four core outcome domains to be assessed in all eczema clinical trials. A number of measurement instruments exist to measure QoL in infants, children, and adolescents with eczema, and there is a great variability in both content and quality of the instruments used. Therefore, the objective of the proposed research is to comprehensively and systematically assess the measurement properties of the existing measurement instruments that were developed and/or validated for the measurement of patient-reported QoL in infants, children, and adolescents with eczema.

Methods/design

This study is a systematic review of the measurement properties of patient-reported measures of QoL developed and/or validated for infants, children, and adolescents with eczema. A systematic literature search will be carried out in MEDLINE via PubMed and EMBASE using a selection of relevant search terms. Eligible studies will be primary empirical studies evaluating, describing, or comparing measurement properties of QoL instruments for infants, children, and adolescents with eczema. Two reviewers will independently perform eligibility assessment and data abstraction. Evidence tables will be used to record study characteristics, instrument characteristics, measurement properties, and interpretability. The adequacy of the measurement properties will be assessed using predefined criteria. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist will be used to evaluate the methodological quality of included studies. A best evidence synthesis will be undertaken if more than one study has examined a particular measurement property.

Discussion

The proposed systematic review will yield a comprehensive assessment of measurement properties of existing QoL instruments in infants, children, and adolescents with eczema. The results will serve as a basis to recommend a QoL measurement instrument for infants, one for children, and one for adolescents for use in future clinical trials.

Systematic review registration

PROSPERO CRD42015023483

Available only for authorised users

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Title: Measurement properties of quality of life measurement instruments for infants, children and adolescents with eczema: protocol for a systematic review
Authors: Daniel Heinl
Cecilia A. C. Prinsen
Aaron M. Drucker
Robert Ofenloch
Rosemary Humphreys
Tracey Sach
Carsten Flohr
Christian Apfelbacher
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Systematic Reviews / Issue 1/2016
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-016-0202-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Measurement properties of quality of life measurement instruments for infants, children and adolescents with eczema: protocol for a systematic review

Abstract

Background

Methods/design

Discussion

Systematic review registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods/design

Discussion

Systematic review registration

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