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Published in: Israel Journal of Health Policy Research 1/2016

Open Access 01-12-2016 | Commentary

Hyperemesis Gravidarum is associated with substantial economic burden in addition to severe physical and psychological suffering

Authors: Jone Trovik, Åse Vikanes

Published in: Israel Journal of Health Policy Research | Issue 1/2016

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Abstract

Hyperemesis gravidarum (HG) affects 1 % of all pregnant women and in western societies it is the most common cause for hospital admission during first trimester. The economic burden of the disease has barely been studied. To estimate the Israeli national burden of HG, Konikoff and co-workers obtained data retrospectively on hospital costs as well as loss of workdays from 184 women hospitalized due to HG from December 2010 until December 2013. Their findings emphasise the need for better treatment to reduce the burden of this disease both for the individual as well as the society.
Literature
1.
go back to reference Poursharif B, Korst LM, Fejzo MS, MacGibbon KW, Romero R, Goodwin TM. The psychosocial burden of hyperemesis gravidarum. J Perinatol. 2008;28(3):176–81.CrossRefPubMed Poursharif B, Korst LM, Fejzo MS, MacGibbon KW, Romero R, Goodwin TM. The psychosocial burden of hyperemesis gravidarum. J Perinatol. 2008;28(3):176–81.CrossRefPubMed
2.
go back to reference Adams MM, Harlass FE, Sarno AP, Read JA, Rawlings JS. Antenatal hospitalization among enlisted servicewomen, 1987–1990. Obstet Gynecol. 1994;84(1):35–9.PubMed Adams MM, Harlass FE, Sarno AP, Read JA, Rawlings JS. Antenatal hospitalization among enlisted servicewomen, 1987–1990. Obstet Gynecol. 1994;84(1):35–9.PubMed
3.
go back to reference Gazmararian JA, Petersen R, Jamieson DJ, Schild L, Adams MM, Deshpande AD, Franks AL. Hospitalizations during pregnancy among managed care enrollees. Obstet Gynecol. 2002;100(1):94–100.PubMed Gazmararian JA, Petersen R, Jamieson DJ, Schild L, Adams MM, Deshpande AD, Franks AL. Hospitalizations during pregnancy among managed care enrollees. Obstet Gynecol. 2002;100(1):94–100.PubMed
4.
go back to reference Vikanes A, Skjaerven R, Grjibovski AM, Gunnes N, Vangen S, Magnus P. Recurrence of hyperemesis gravidarum across generations: population based cohort study. BMJ. 2010;340:c2050.PubMedPubMedCentral Vikanes A, Skjaerven R, Grjibovski AM, Gunnes N, Vangen S, Magnus P. Recurrence of hyperemesis gravidarum across generations: population based cohort study. BMJ. 2010;340:c2050.PubMedPubMedCentral
5.
go back to reference Zhang Y, Cantor RM, MacGibbon K, Romero R, Goodwin TM, Mullin PM, Fejzo MS. Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol. 2011;204(3):230 e231–237.CrossRef Zhang Y, Cantor RM, MacGibbon K, Romero R, Goodwin TM, Mullin PM, Fejzo MS. Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol. 2011;204(3):230 e231–237.CrossRef
6.
go back to reference Corey LA, Berg K, Solaas MH, Nance WE. The epidemiology of pregnancy complications and outcome in a Norwegian twin population. Obstet Gynecol. 1992;80(6):989–94.PubMed Corey LA, Berg K, Solaas MH, Nance WE. The epidemiology of pregnancy complications and outcome in a Norwegian twin population. Obstet Gynecol. 1992;80(6):989–94.PubMed
7.
go back to reference Niemeijer MN, Grooten IJ, Vos N, Bais JM, van der Post JA, Mol BW, Roseboom TJ, Leeflang MM, Painter RC. Diagnostic markers for hyperemesis gravidarum: a systematic review and metaanalysis. Am J Obstet Gynecol. 2014;211(2):150 e151–115.CrossRef Niemeijer MN, Grooten IJ, Vos N, Bais JM, van der Post JA, Mol BW, Roseboom TJ, Leeflang MM, Painter RC. Diagnostic markers for hyperemesis gravidarum: a systematic review and metaanalysis. Am J Obstet Gynecol. 2014;211(2):150 e151–115.CrossRef
8.
go back to reference Li L, Li L, Zhou X, Xiao S, Gu H, Zhang G. Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis. Gastroenterol Res Pract. 2015;2015:278905.PubMedPubMedCentral Li L, Li L, Zhou X, Xiao S, Gu H, Zhang G. Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis. Gastroenterol Res Pract. 2015;2015:278905.PubMedPubMedCentral
10.
go back to reference Konikoff T, Avraham T, Ophir E, Bornstein J. Hyperemesis Gravidarum in northern Israel: an epidemiological retrospective study. Isr J of Health Policy Res. 2016; doi:10.1186/s13584-016-0100-9. Konikoff T, Avraham T, Ophir E, Bornstein J. Hyperemesis Gravidarum in northern Israel: an epidemiological retrospective study. Isr J of Health Policy Res. 2016; doi:10.​1186/​s13584-016-0100-9.
11.
go back to reference Vikanes AV, Stoer NC, Magnus P, Grjibovski AM. Hyperemesis gravidarum and pregnancy outcomes in the Norwegian Mother and Child Cohort - a cohort study. BMC Pregnancy Childbirth. 2013;13:169.CrossRefPubMedPubMedCentral Vikanes AV, Stoer NC, Magnus P, Grjibovski AM. Hyperemesis gravidarum and pregnancy outcomes in the Norwegian Mother and Child Cohort - a cohort study. BMC Pregnancy Childbirth. 2013;13:169.CrossRefPubMedPubMedCentral
12.
go back to reference Einarson TR, Piwko C, Koren G. Prevalence of nausea and vomiting of pregnancy in the USA: a meta analysis. J Popul Ther Clin Pharmacol. 2013;20(2):e163–170.PubMed Einarson TR, Piwko C, Koren G. Prevalence of nausea and vomiting of pregnancy in the USA: a meta analysis. J Popul Ther Clin Pharmacol. 2013;20(2):e163–170.PubMed
13.
go back to reference Fiaschi L, Nelson-Piercy C, Tata LJ. Hospital admission for hyperemesis gravidarum: a nationwide study of occurrence, reoccurrence and risk factors among 8.2 million pregnancies. Hum Reprod. 2016;31(8):1675–84.CrossRefPubMed Fiaschi L, Nelson-Piercy C, Tata LJ. Hospital admission for hyperemesis gravidarum: a nationwide study of occurrence, reoccurrence and risk factors among 8.2 million pregnancies. Hum Reprod. 2016;31(8):1675–84.CrossRefPubMed
14.
go back to reference Matsuo K, Ushioda N, Nagamatsu M, Kimura T. Hyperemesis gravidarum in Eastern Asian population. Gynecol Obstet Invest. 2007;64(4):213–6.CrossRefPubMed Matsuo K, Ushioda N, Nagamatsu M, Kimura T. Hyperemesis gravidarum in Eastern Asian population. Gynecol Obstet Invest. 2007;64(4):213–6.CrossRefPubMed
15.
go back to reference Vikanes A, Grjibovski AM, Vangen S, Magnus P. Variations in prevalence of hyperemesis gravidarum by country of birth: a study of 900,074 pregnancies in Norway, 1967–2005. Scand J Public Health. 2008;36(2):135–42.CrossRefPubMed Vikanes A, Grjibovski AM, Vangen S, Magnus P. Variations in prevalence of hyperemesis gravidarum by country of birth: a study of 900,074 pregnancies in Norway, 1967–2005. Scand J Public Health. 2008;36(2):135–42.CrossRefPubMed
16.
go back to reference McCarthy FP, Lutomski JE, Greene RA. Hyperemesis gravidarum: current perspectives. Int J Women's Health. 2014;6:719–25. McCarthy FP, Lutomski JE, Greene RA. Hyperemesis gravidarum: current perspectives. Int J Women's Health. 2014;6:719–25.
17.
go back to reference Bashiri A, Neumann L, Maymon E, Katz M. Hyperemesis gravidarum: epidemiologic features, complications and outcome. Eur J Obstet Gynecol Reprod Biol. 1995;63(2):135–8.CrossRefPubMed Bashiri A, Neumann L, Maymon E, Katz M. Hyperemesis gravidarum: epidemiologic features, complications and outcome. Eur J Obstet Gynecol Reprod Biol. 1995;63(2):135–8.CrossRefPubMed
18.
go back to reference Wood H, McKellar LV, Lightbody M. Nausea and vomiting in pregnancy: blooming or bloomin' awful? A review of the literature. Women Birth. 2013;26(2):100–4.CrossRefPubMed Wood H, McKellar LV, Lightbody M. Nausea and vomiting in pregnancy: blooming or bloomin' awful? A review of the literature. Women Birth. 2013;26(2):100–4.CrossRefPubMed
19.
go back to reference Lacroix R, Eason E, Melzack R. Nausea and vomiting during pregnancy: A prospective study of its frequency, intensity, and patterns of change. Am J Obstet Gynecol. 2000;182(4):931–7.CrossRefPubMed Lacroix R, Eason E, Melzack R. Nausea and vomiting during pregnancy: A prospective study of its frequency, intensity, and patterns of change. Am J Obstet Gynecol. 2000;182(4):931–7.CrossRefPubMed
20.
go back to reference Mazzotta P, Stewart DE, Koren G, Magee LA. Factors associated with elective termination of pregnancy among Canadian and American women with nausea and vomiting of pregnancy. J Psychosom Obstet Gynaecol. 2001;22(1):7–12.CrossRefPubMed Mazzotta P, Stewart DE, Koren G, Magee LA. Factors associated with elective termination of pregnancy among Canadian and American women with nausea and vomiting of pregnancy. J Psychosom Obstet Gynaecol. 2001;22(1):7–12.CrossRefPubMed
21.
go back to reference Poursharif B, Korst LM, Macgibbon KW, Fejzo MS, Romero R, Goodwin TM. Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum. Contraception. 2007;76(6):451–5.CrossRefPubMed Poursharif B, Korst LM, Macgibbon KW, Fejzo MS, Romero R, Goodwin TM. Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum. Contraception. 2007;76(6):451–5.CrossRefPubMed
22.
go back to reference Koren G, Piwko C, Ahn E, Boskovic R, Maltepe C, Einarson A, Navioz Y, Ungar WJ. Validation studies of the Pregnancy Unique-Quantification of Emesis (PUQE) scores. J Obstet Gynaecol. 2005;25(3):241–4.CrossRefPubMed Koren G, Piwko C, Ahn E, Boskovic R, Maltepe C, Einarson A, Navioz Y, Ungar WJ. Validation studies of the Pregnancy Unique-Quantification of Emesis (PUQE) scores. J Obstet Gynaecol. 2005;25(3):241–4.CrossRefPubMed
23.
go back to reference Birkeland E, Stokke G, Tangvik RJ, Torkildsen EA, Boateng J, Wollen AL, Albrechtsen S, Flaatten H, Trovik J. Norwegian PUQE (Pregnancy-Unique Quantification of Emesis and nausea) identifies patients with hyperemesis gravidarum and poor nutritional intake: a prospective cohort validation study. PLoS One. 2015;10(4):e0119962.CrossRefPubMedPubMedCentral Birkeland E, Stokke G, Tangvik RJ, Torkildsen EA, Boateng J, Wollen AL, Albrechtsen S, Flaatten H, Trovik J. Norwegian PUQE (Pregnancy-Unique Quantification of Emesis and nausea) identifies patients with hyperemesis gravidarum and poor nutritional intake: a prospective cohort validation study. PLoS One. 2015;10(4):e0119962.CrossRefPubMedPubMedCentral
24.
go back to reference Piwko C, Ungar WJ, Einarson TR, Wolpin J, Koren G. The weekly cost of nausea and vomiting of pregnancy for women calling the Toronto Motherisk Program. Curr Med Res Opin. 2007;23(4):833–40.CrossRefPubMed Piwko C, Ungar WJ, Einarson TR, Wolpin J, Koren G. The weekly cost of nausea and vomiting of pregnancy for women calling the Toronto Motherisk Program. Curr Med Res Opin. 2007;23(4):833–40.CrossRefPubMed
25.
go back to reference Piwko C, Koren G, Babashov V, Vicente C, Einarson TR. Economic burden of nausea and vomiting of pregnancy in the USA. J Popul Ther Clin Pharmacol. 2013;20(2):e149–160.PubMed Piwko C, Koren G, Babashov V, Vicente C, Einarson TR. Economic burden of nausea and vomiting of pregnancy in the USA. J Popul Ther Clin Pharmacol. 2013;20(2):e149–160.PubMed
27.
go back to reference Neutel CI, Johansen HL. Measuring drug effectiveness by default: the case of Bendectin. Can J Public Health. 1995;86(1):66–70.PubMed Neutel CI, Johansen HL. Measuring drug effectiveness by default: the case of Bendectin. Can J Public Health. 1995;86(1):66–70.PubMed
28.
go back to reference Trogstad LI, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM. Recurrence risk in hyperemesis gravidarum. BJOG. 2005;112(12):1641–5.CrossRefPubMed Trogstad LI, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM. Recurrence risk in hyperemesis gravidarum. BJOG. 2005;112(12):1641–5.CrossRefPubMed
29.
go back to reference Maltepe C, Koren G. Preemptive treatment of nausea and vomiting of pregnancy: results of a randomized controlled trial. Obstet Gynecol Int. 2013;2013:809787. doi:10.1155/2013/80978. Maltepe C, Koren G. Preemptive treatment of nausea and vomiting of pregnancy: results of a randomized controlled trial. Obstet Gynecol Int. 2013;2013:809787. doi:10.​1155/​2013/​80978.
30.
go back to reference McCarthy FP, Murphy A, Khashan AS, McElroy B, Spillane N, Marchocki Z, Sarkar R, Higgins JR. Day care compared with inpatient management of nausea and vomiting of pregnancy: a randomized controlled trial. Obstet Gynecol. 2014;124(4):743–8.CrossRefPubMed McCarthy FP, Murphy A, Khashan AS, McElroy B, Spillane N, Marchocki Z, Sarkar R, Higgins JR. Day care compared with inpatient management of nausea and vomiting of pregnancy: a randomized controlled trial. Obstet Gynecol. 2014;124(4):743–8.CrossRefPubMed
31.
go back to reference McParlin C, Carrick-Sen D, Steen IN, Robson SC. Hyperemesis in Pregnancy Study: a pilot randomised controlled trial of midwife-led outpatient care. Eur J Obstet Gynecol Reprod Biol. 2016;200:6–10.CrossRefPubMed McParlin C, Carrick-Sen D, Steen IN, Robson SC. Hyperemesis in Pregnancy Study: a pilot randomised controlled trial of midwife-led outpatient care. Eur J Obstet Gynecol Reprod Biol. 2016;200:6–10.CrossRefPubMed
32.
go back to reference Murphy A, McCarthy FP, McElroy B, Khashan AS, Spillane N, Marchocki Z, Sarkar RK, Higgins JR. Day care versus inpatient management of nausea and vomiting of pregnancy: cost utility analysis of a randomised controlled trial. Eur J Obstet Gynecol Reprod Biol. 2016;197:78–82.CrossRefPubMed Murphy A, McCarthy FP, McElroy B, Khashan AS, Spillane N, Marchocki Z, Sarkar RK, Higgins JR. Day care versus inpatient management of nausea and vomiting of pregnancy: cost utility analysis of a randomised controlled trial. Eur J Obstet Gynecol Reprod Biol. 2016;197:78–82.CrossRefPubMed
33.
go back to reference van Stuijvenberg ME, Schabort I, Labadarios D, Nel JT. The nutritional status and treatment of patients with hyperemesis gravidarum. Am J Obstet Gynecol. 1995;172(5):1585–91.CrossRefPubMed van Stuijvenberg ME, Schabort I, Labadarios D, Nel JT. The nutritional status and treatment of patients with hyperemesis gravidarum. Am J Obstet Gynecol. 1995;172(5):1585–91.CrossRefPubMed
34.
go back to reference Folk JJ, Leslie-Brown HF, Nosovitch JT, Silverman RK, Aubry RH. Hyperemesis gravidarum: outcomes and complications with and without total parenteral nutrition. J Reprod Med. 2004;49(7):497–502.PubMed Folk JJ, Leslie-Brown HF, Nosovitch JT, Silverman RK, Aubry RH. Hyperemesis gravidarum: outcomes and complications with and without total parenteral nutrition. J Reprod Med. 2004;49(7):497–502.PubMed
35.
go back to reference Holmgren C, Aagaard-Tillery KM, Silver RM, Porter TF, Varner M. Hyperemesis in pregnancy: an evaluation of treatment strategies with maternal and neonatal outcomes. Am J Obstet Gynecol. 2008;198(1):56 e51–54.CrossRef Holmgren C, Aagaard-Tillery KM, Silver RM, Porter TF, Varner M. Hyperemesis in pregnancy: an evaluation of treatment strategies with maternal and neonatal outcomes. Am J Obstet Gynecol. 2008;198(1):56 e51–54.CrossRef
36.
go back to reference Stokke G, Gjelsvik BL, Flaatten KT, Birkeland E, Flaatten H, Trovik J. Hyperemesis gravidarum, nutritional treatment by nasogastric tube feeding: a 10-year retrospective cohort study. Acta Obstet Gynecol Scand. 2015;94(4):359–67.CrossRefPubMed Stokke G, Gjelsvik BL, Flaatten KT, Birkeland E, Flaatten H, Trovik J. Hyperemesis gravidarum, nutritional treatment by nasogastric tube feeding: a 10-year retrospective cohort study. Acta Obstet Gynecol Scand. 2015;94(4):359–67.CrossRefPubMed
37.
go back to reference Pritchard C, Duffy S, Edington J, Pang F. Enteral nutrition and oral nutrition supplements: a review of the economics literature. JPEN. 2006;30(1):52–9.CrossRef Pritchard C, Duffy S, Edington J, Pang F. Enteral nutrition and oral nutrition supplements: a review of the economics literature. JPEN. 2006;30(1):52–9.CrossRef
Metadata
Title
Hyperemesis Gravidarum is associated with substantial economic burden in addition to severe physical and psychological suffering
Authors
Jone Trovik
Åse Vikanes
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Israel Journal of Health Policy Research / Issue 1/2016
Electronic ISSN: 2045-4015
DOI
https://doi.org/10.1186/s13584-016-0099-y

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