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Clinical Sarcoma Research
Published in: Clinical Sarcoma Research 1/2018

Open Access 01-12-2018 | Case report

Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour

Authors: G. L. Tiemeier, J. M. Brown, S. E. Pratap, C. McCarthy, A. Kastrenopoulou, K. Bradley, S. Wilson, Z. Orosz, C. L. M. H. Gibbons, U. Oppermann, N. A. Athanasou

Published in: Clinical Sarcoma Research | Issue 1/2018

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Abstract

Background

Liposarcoma is an extremely rare primary bone sarcoma.

Case presentation

We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17.1) in the primary tumour as well as a metastasis in the right distal femur and multiple small pulmonary metastases. Histologically, the tumour was a pleomorphic liposarcoma containing large tumour cells with vacuolated cytoplasm and hyperchromatic pleomorphic nuclei as well as numerous lipoblasts and scattered brown fat-like cells. Tumour cells strongly expressed FABP4/aP2, a marker of adipocyte differentiation, and UCP1, a marker of brown fat, but not S100. The case was treated with neoadjuvant MAP chemotherapy, resulting in extensive (> 95%) necrosis in the primary tumour and almost complete resolution of the femoral and pulmonary metastases.

Conclusions

Pleomorphic liposarcoma can present as a sclerotic primary malignant bone tumour; markers of adipose differentiation are useful in histological diagnosis and neoadjuvant MAP chemotherapy results in significant tumor necrosis.
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Metadata
Title
Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour
Authors
G. L. Tiemeier
J. M. Brown
S. E. Pratap
C. McCarthy
A. Kastrenopoulou
K. Bradley
S. Wilson
Z. Orosz
C. L. M. H. Gibbons
U. Oppermann
N. A. Athanasou
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Clinical Sarcoma Research / Issue 1/2018
Electronic ISSN: 2045-3329
DOI
https://doi.org/10.1186/s13569-018-0089-7

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