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Open Access 01-12-2016 | Case report

Metastatic meningioma presenting as a malignant soft tissue tumour

Authors: Catherine McCarthy, Monika Hofer, Marianna Vlychou, Robar Khundkar, Paul Critchley, Simon Cudlip, Olaf Ansorge, Nick A. Athanasou

Published in: Clinical Sarcoma Research | Issue 1/2016

Abstract

Background

Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

Case presentation

We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscle. The patient had previously undergone surgery for a right frontal lobe high grade anaplastic meningioma. Histology of the soft tissue lesion showed metastatic anaplastic meningioma with clumps of pleomorphic tumour cells which expressed epithelial membrane antigen, cytokeratin and P63 but were negative for other epithelial and mesenchymal markers. A PET-CT scan revealed additional metastatic lesions in the left pleura, liver and iliac bone.

Conclusions

Metastatic malignant meningioma can very rarely present as a high grade pleomorphic malignant soft tissue tumour and needs to be distinguished from soft tissue sarcomas and metastatic carcinomas that express epithelial antigens.

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Title: Metastatic meningioma presenting as a malignant soft tissue tumour
Authors: Catherine McCarthy
Monika Hofer
Marianna Vlychou
Robar Khundkar
Paul Critchley
Simon Cudlip
Olaf Ansorge
Nick A. Athanasou
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Clinical Sarcoma Research / Issue 1/2016
Electronic ISSN: 2045-3329
DOI: https://doi.org/10.1186/s13569-016-0063-1

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