An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [^64/67Cu]Cu-SARTATE

In a preclinical model of neuroblastoma, Dearling et al. recently demonstrated the potential interest for a theranostic approach of [⁶⁴/⁶⁷Cu]Cu-SARTATE for the detection and treatment of SSTR2-positive neuroblastoma lesions in pediatric patients whose widespread metastases survive initial therapy as minimal residual disease (MRD). MRD may be detected by [⁶⁴Cu]Cu-SARTATE and subsequently treated by [⁶⁷Cu]Cu-SARTATE. Since therapeutic dosimetry estimation of the latter agent from the uptake of the former one in the initial diagnostic scan was not addressed, the present theoretical commentary proposes the derivation of an abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [⁶⁴/⁶⁷Cu]Cu-SARTATE that might be of interest for future clinical theranostic practice.