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EJNMMI Research
Published in: EJNMMI Research 1/2015

Open Access 01-12-2015 | Review

Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging

Authors: Dan Li, Li He, Huizhuang Guo, Hanwei Chen, Hong Shan

Published in: EJNMMI Research | Issue 1/2015

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Abstract

Following injurious stimuli, quiescent hepatic stellate cells (qHSCs) transdifferentiate into activated HSCs (aHSCs). aHSCs play pivotal roles in the onset and progression of liver fibrosis. Therefore, molecular imaging of aHSCs in liver fibrosis will facilitate early diagnosis, prognosis prediction, and instruction and evaluation of aHSC-targeted treatment. To date, several receptors, such as integrin αvβ3, mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF-IIR), collagen type VI receptor (CVIR), platelet-derived growth factor receptor-β (PDGFR-β), vimentin, and desmin, have been identified as biomarkers of aHSCs. Corresponding ligands to these receptors have also been developed. This review will discuss strategies for developing aHSC-targeted imaging in liver fibrosis.
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Metadata
Title
Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging
Authors
Dan Li
Li He
Huizhuang Guo
Hanwei Chen
Hong Shan
Publication date
01-12-2015
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2015
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/s13550-015-0151-x

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