Top

Published in:

Open Access 01-12-2023 | Endocarditis | Case report

Infectious endocarditis caused by Bartonella henselae associated with infected pets: two case reports

Authors: Jonathan Gonçalves-Oliveira, Paulo Vieira Damasco, Matheus Ribeiro da S. Assis, Dominique E. Freitas, Adonai Alvino Pessoa Junior, Luiza S. de Sousa, Nicollas G. Rodrigues, Paula H. Damasco, Pedro F. Ribeiro, Giovanna F. Barbosa, Namir S. Moreira, Jeferson F. Guedes, Henrique M. da Rocha Coutinho, Kalil Madi, Elba R. Sampaio de Lemos

Published in: Journal of Medical Case Reports | Issue 1/2023

Abstract

Background

Blood culture-negative infective endocarditis is a potentially severe disease that can be associated with infectious agents such as Bartonella spp., Coxiella burnetti, Tropheryma whipplei, and some fungi.

Case presentation

Reported here are two cases of blood culture-negative infective endocarditis in patients with severe aortic and mitral regurgitation in Brazil; the first case is a 47-year-old white man and the second is a 62-year-old white woman. Bartonella henselae deoxyribonucleic acid was detectable in the blood samples and cardiac valve with vegetation paraffin-fixed tissue samples. Additionally, an investigation was carried out on patients’ pets, within the context of One Health, and serum samples collected from cats and dogs were reactive by indirect immunofluorescence assay.

Conclusions

Even though the frequency of bartonellosis in Brazil is unknown, physicians should be aware of the possibility of blood culture-negative infective endocarditis caused by Bartonella, particularly in patients with weight loss, kidney changes, and epidemiological history for domestic animals.

Available only for authorised users

Baddour LM, Wilson WR, Bayer AS, Fowler VG, Tleyjeh IM, Rybak MJ, Barsic B, Lockhart PB, Gewitz MH, Levison ME, Bolger AF, Steckelberg JM, Baltimore RS, Fink AM, O’Gara P, Taubert KA. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications. Circulation. 2015;132:1435–86. https://doi.org/10.1161/CIR.0000000000000296.CrossRefPubMed

Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J-P, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL. ESC Guidelines for the management of infective endocarditis. Eur Heart J. 2015;36(2015):3075–128. https://doi.org/10.1093/eurheartj/ehv319.CrossRefPubMed

Vincent LL, Otto CM. Infective endocarditis: update on epidemiology, outcomes, and management. Curr Cardiol Rep. 2018;20:86. https://doi.org/10.1007/s11886-018-1043-2.CrossRefPubMed

Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG, Ryan T, Bashore T, Corey GR. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30:633–8. https://doi.org/10.1086/313753.CrossRefPubMed

Damasco PV, Correal JC, Cruz-Campos AC, Wajsbrot BR, Cunha RG, Fonseca AG, Castier MB, Fortes CQ, Jazbick JC, Lemos ER, Rossen JW, de Souza RL, Hirata Junior R, de Mattos Guaraldi AL. Guaraldi, Epidemiological and clinical profile of infective endocarditis at a Brazilian tertiary care center: An eight-year prospective study. Rev Soc Bras Med Trop. 2019;52:1–9. https://doi.org/10.1590/0037-8682-0375-2018.CrossRef

Liesman RM, Pritt BS, Maleszewski JJ, Patel R. Laboratory diagnostic endocarditis. J Clin Microbiol. 2017;55:2599–608.CrossRefPubMedPubMedCentral

Werner M, Fournier P-E, Andersson R, Hogevik H, Raoult D. Bartonella and Coxiella antibodies in 334 prospectively studied episodes of infective endocarditis in Sweden. Scand J Infect Dis. 2003;35:724–7. https://doi.org/10.1080/00365540310015980.CrossRefPubMed

Siciliano RF, Strabelli TM, Zeigler R, Rodrigues C, Castelli JB, Grinberg M, Colombo S, da Silva LJ, do Nascimento EM, dos Santos EM, Uip DE. Infective endocarditis due to Bartonella spp. and Coxiella burnetii: experience at a cardiology hospital in São Paulo, Brazil. Ann NY Acad Sci. 2006;1078:215–22. https://doi.org/10.1196/annals.1374.123.CrossRefPubMed

da Cruz Lamas C, Ramos RG, Lopes GQ, Santos MS, Golebiovski WF, Weksler C, Ferraiuoli GI, Fournier PE, Lepidi H, Raoult D. Raoult, Bartonella and Coxiella infective endocarditis in Brazil: molecular evidence from excised valves from a cardiac surgery referral center in Rio de Janeiro, Brazil, 1998 to 2009. Int J Infect Dis. 2013;17:e955–6. https://doi.org/10.1016/j.ijid.2012.10.009.CrossRef

10.

Breitschwerdt EB. Bartonellosis: One Health perspectives for an emerging infectious disease. ILAR J. 2014;55:46–58. https://doi.org/10.1093/ilar/ilu015.CrossRefPubMed

11.

Chomel BB, Kasten RW. Bartonellosis, an increasingly recognized zoonosis. J Appl Microbiol. 2010;109:743–50. https://doi.org/10.1111/j.1365-2672.2010.04679.x.CrossRefPubMed

12.

Guptill L. Bartonellosis. Vet Microbiol. 2010;140:347–59. https://doi.org/10.1016/j.vetmic.2009.11.011.CrossRefPubMed

13.

Koehler JE. Rochalimaea henselae Infection. JAMA. 1994;271:531. https://doi.org/10.1001/jama.1994.03510310061039.CrossRefPubMed

14.

de Paiva Diniz PP, Maggi R, Schwartz D, Cadenas M, Bradley J, Hegarty B, Breitschwerdt E. Canine bartonellosis: serological and molecular prevalence in Brazil and evidence of co-infection with Bartonella henselae and Bartonella vinsonii subsp. Berkhoffii. Vet Res. 2007;38:697–710. https://doi.org/10.1051/vetres:2007023.CrossRef

15.

Bessas A, Leulmi H, Bitam I, Zaidi S, Ait-Oudhia K, Raoult D, Parola P. Molecular evidence of vector-borne pathogens in dogs and cats and their ectoparasites in Algiers, Algeria. Comp Immunol Microbiol Infect Dis. 2016;45:23–8. https://doi.org/10.1016/j.cimid.2016.01.002.CrossRefPubMed

16.

Breitschwerdt EB, Maggi RG, Chomel BB, Lappin MR. Bartonellosis: an emerging infectious disease of zoonotic importance to animals and human beings. J Vet Emerg Crit Care. 2010;20:8–30. https://doi.org/10.1111/j.1476-4431.2009.00496.x.CrossRef

17.

André MR, Canola RA, Braz JB, Perossi IF, Calchi AC, Ikeda P, Machado RZ, Vasconcelos RD, Camacho AA. Aortic valve endocarditis due to Bartonella clarridgeiae in a dog in Brazil. Rev Bras Parasitol Vet. 2019;28:661–70. https://doi.org/10.1590/s1984-29612019078.CrossRefPubMed

18.

Tabar M-D, Altet L, Maggi RG, Altimira J, Roura X. First description of Bartonella koehlerae infection in a Spanish dog with infective endocarditis. Parasit Vectors. 2017;10:247. https://doi.org/10.1186/s13071-017-2188-3.CrossRefPubMedPubMedCentral

19.

Breitschwerdt EB. Bartonellosis, One Health and all creatures great and small. Vet Dermatol. 2017;28:96-e21. https://doi.org/10.1111/vde.12413.CrossRefPubMed

20.

Beerlage C, Varanat M, Linder K, Maggi RG, Cooley J, Kempf VA, Breitschwerdt EB. Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals. Med Microbiol Immunol. 2012;201:319–26. https://doi.org/10.1007/s00430-012-0234-5.CrossRefPubMed

21.

Gibbs EPJ. The evolution of One Health: a decade of progress and challenges for the future. Vet Rec. 2014;174:85–91. https://doi.org/10.1136/vr.g143.CrossRefPubMed

22.

Siciliano RF, Castelli JB, Mansur AJ, Dos Santos FP, Colombo S, Do Nascimento EM, Paddock CD, Brasil RA, Velho PE, Drummond MR, Grinberg M, Strabelli TMV. Bartonella spp. and Coxiella burnetii associated with community-acquired, culture-negative endocarditis, Brazil. Emerg Infect Dis. 2015;21:1429–32. https://doi.org/10.3201/eid2108.140343.CrossRefPubMedPubMedCentral

23.

Lamas C, Favacho A, Ramos RG, Santos MS, Ferravoli GI, Weksler C, Rozental T, Bóia MN, Lemos ERS. Bartonella native valve endocarditis: the first Brazilian case alive and well, Brazilian. J Infect Dis. 2007;11:591–4. https://doi.org/10.1590/S1413-86702007000600012.CrossRef

24.

Drummond MR, de Almeida AR, Valandro L, Pavan MH, Stucchi RS, Aoki FH, Velho PE. Bartonella henselae endocarditis in an elderly patient. PLoS Negl Trop Dis. 2020;14: e0008376. https://doi.org/10.1371/journal.pntd.0008376.CrossRefPubMedPubMedCentral

25.

Corrêa FG, Pontes CLS, Verzola RMM, Mateos JCP, Velho PENF, Schijman AG, Selistre-de-Araujo HS. Association of Bartonella spp bacteremia with Chagas cardiomyopathy, endocarditis and arrhythmias in patients from South America, Brazilian. J Med Biol Res. 2012;45:644–51. https://doi.org/10.1590/S0100-879X2012007500082.CrossRef

26.

Chomel BB, Kasten RW, Floyd-Hawkins K, Chi B, Yamamoto K, Roberts-Wilson J, Gurfield AN, Abbott RC, Pedersen NC, Koehler JE. Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol. 1996;34:1952–6. https://doi.org/10.1128/jcm.34.8.1952-1956.1996.CrossRefPubMedPubMedCentral

27.

Iannino F, Salucci S, Di Provvido A, Paolini A, Ruggieri E. Bartonella infections in humans dogs and cats. Vet Ital. 2018;54:63–72. https://doi.org/10.12834/VetIt.398.1883.2.CrossRefPubMed

28.

Lamas CC, Mares-Guia MA, Rozental T, Moreira N, Favacho AR, Barreira J, Guterres A, Bóia MN, de Lemos ER. Bartonella spp. infection in HIV positive individuals, their pets and ectoparasites in Rio de Janeiro, Brazil: serological and molecular study. Acta Trop. 2010;115:137–41. https://doi.org/10.1016/j.actatropica.2010.02.015.CrossRefPubMed

29.

Regier Y, Órourke F, Kempf VAJ. Bartonella spp.—a chance to establish One Health concepts in veterinary and human medicine. Parasites Vectors. 2016;9:1–12. https://doi.org/10.1186/s13071-016-1546-x.CrossRef

30.

Kosoy M, Bai Y. Bartonella bacteria in urban rats: a movement from the jungles of Southeast Asia to metropoles around the globe. Front Ecol Evol. 2019;7:1–17. https://doi.org/10.3389/fevo.2019.00088.CrossRef

31.

Kearse M, Moir R, Wilson A, Stones-Havas S, Cheung M, Sturrock S, Buxton S, Cooper A, Markowitz S, Duran C, Thierer T, Ashton B, Meintjes P, Drummond A. Geneious basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics. 2012;28:1647–9. https://doi.org/10.1093/bioinformatics/bts199.CrossRefPubMedPubMedCentral

Title: Infectious endocarditis caused by Bartonella henselae associated with infected pets: two case reports
Authors: Jonathan Gonçalves-Oliveira
Paulo Vieira Damasco
Matheus Ribeiro da S. Assis
Dominique E. Freitas
Adonai Alvino Pessoa Junior
Luiza S. de Sousa
Nicollas G. Rodrigues
Paula H. Damasco
Pedro F. Ribeiro
Giovanna F. Barbosa
Namir S. Moreira
Jeferson F. Guedes
Henrique M. da Rocha Coutinho
Kalil Madi
Elba R. Sampaio de Lemos
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: Endocarditis
Published in: Journal of Medical Case Reports / Issue 1/2023
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-023-03839-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Infectious endocarditis caused by Bartonella henselae associated with infected pets: two case reports

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2023

Denosumab-induced hypocalcemia post bariatric surgery—a severe and protracted course: a case report

Acquired hemophilia A following COVID-19 vaccine: a case report

Failure of diltiazem to prevent 1:1 conduction of atrial flutter: a case report

Multiple maxillary periodontal abscesses as a manifestation of post-coronavirus disease 2019 mucormycosis: a case report

Serratia marcescens prosthetic joint infection: two case reports and a review of the literature

Endocarditis caused by Aspergillus fumigatus in a patient 9 months after COVID-19 infection recovery: a case report and review of the literature