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Journal of Medical Case Reports

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Open Access 01-12-2021 | Magnetic Resonance Imaging | Case report

Uncertainty of leukoencephalopathies: a case report

Authors: Mohamed A. Taha, T. Scott Diesing

Published in: Journal of Medical Case Reports | Issue 1/2021

Abstract

Background

Adult-onset leukoencephalopathies are a group of heterogeneous disorders characterized by white matter abnormalities. Leukoencephalopathy is usually encountered in children, but here we report a case with adult-onset leukoencephalopathy. Also, we explore this concept of uncertainty in medicine by discussing the approach to this case that has multiple possible etiologies.

Case presentation

A 70-year-old Caucasian male presented with a subacute onset of cognitive impairment and mood disturbances associated with behavioral changes. Neuroimaging demonstrated high-intensity lesions involving cerebral white matter. Progressive dementia and cognitive decline followed. Multiple possible etiologies are discussed based on the patient presentation and risk factors.

Conclusion

Adult-onset leukoencephalopathy can become a diagnostic challenge. Certain approaches need to be developed to explore the uncertainty of such conditions and to improve diagnostic yield.

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Title: Uncertainty of leukoencephalopathies: a case report
Authors: Mohamed A. Taha
T. Scott Diesing
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Creutzfeldt-Jakob Disease
Methotrexate
Dementia
Methotrexate
Dementia
Leukodystrophy
Published in: Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-021-03089-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Uncertainty of leukoencephalopathies: a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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