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Journal of Medical Case Reports

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Open Access 01-12-2021 | Sarcoidosis | Case report

Melkersson–Rosenthal syndrome in the context of sarcoidosis: a case report

Authors: J. Casper, S. Mohammad-Khani, J. J. Schmidt, J. T. Kielstein, T. Lenarz, H. Haller, Annette D. Wagner

Published in: Journal of Medical Case Reports | Issue 1/2021

Abstract

Background

Melkersson–Rosenthal syndrome is a rare disease characterized by the triad of recurrent orofacial swelling with facial paralysis and fissured dorsal tongue. Histologically, noncaseating granulomatous inflammation occurs that confirms the diagnosis. Overlaps between granulomatous diseases such as sarcoidosis and Crohn’s disease are described. Systemic corticosteroid therapy is the treatment of choice for acute attacks.

Case presentation

We here present a case of a 59-year-old White woman suffering from Melkersson–Rosenthal syndrome with a past history of sarcoidosis on therapy with leflunomide in combination with low-dose tacrolimus successfully treated with the anti-leprosy drug clofazimine after failure of systemic steroid therapy.

Conclusions

We propose clofazimine as an alternative treatment in steroid-refractory cases.

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Title: Melkersson–Rosenthal syndrome in the context of sarcoidosis: a case report
Authors: J. Casper
S. Mohammad-Khani
J. J. Schmidt
J. T. Kielstein
T. Lenarz
H. Haller
Annette D. Wagner
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Sarcoidosis
Leflunomide
Sarcoidosis
Published in: Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-021-03044-5

ACC 2024 Congress

Springer Medicine

Melkersson–Rosenthal syndrome in the context of sarcoidosis: a case report

Abstract

Background

Case presentation

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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