Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2021

Open Access 01-12-2021 | Infertility | Case report

Embryo transfer can be performed in either uterine horn. Two successive pregnancies in a patient with uterus didelphys: a case report

Author: Zakwan Khrait

Published in: Journal of Medical Case Reports | Issue 1/2021

Login to get access

Abstract

Background

Uterus didelphys results from a failure in Mullerian duct fusion and may be associated with complete or partial vaginal septa. Most cases of uterus didelphys are discovered incidentally during the workup of infertility or recurrent miscarriage. The incidence of uterus didelphys has been reported to be 0.2% in the infertile population.

Case presentation

A 35-year-old white Arab woman, gravida 0, parity 0, with a history of primary infertility of 8 years (a well-known male factor) presented to our infertility center. She was diagnosed as having uterus didelphys with severe male factor. The patient had three previous failed in vitro fertilization/intracytoplasmic sperm injection cycles outside our center.
This is a case report of an infertile woman with uterus didelphys who conceived twice following single embryo transfer in both uterine horns successively. After the first successful pregnancy in the left uterine horn, the initial decision was to transfer the embryo to the same horn (left) because of the previous successful transfer. The very deep and long vagina forced us to reach one of the cervices, in which the embryo was placed in the right uterine horn, followed by the second successful pregnancy in the other, smaller horn. The patient gave her informed consent, both verbal and written, to use her information and images for medical publication.

Conclusion

Pregnancy is possible in women with uterus didelphys using single embryo transfer in in vitro fertilization/intracytoplasmic sperm injection cycles. It is recommended that both horns be given a chance.
Literature
1.
go back to reference Saravelos SH, Cocksedge KA, Li TC. Prevalence and diagnosis congenital uterine anomalies in women with reproductive failure: a critical appraisal. Hum Reprod Update. 2008;14:415–29.CrossRef Saravelos SH, Cocksedge KA, Li TC. Prevalence and diagnosis congenital uterine anomalies in women with reproductive failure: a critical appraisal. Hum Reprod Update. 2008;14:415–29.CrossRef
2.
go back to reference Yang MJ, Tseng JY, Chen CY, Li HY. Delivery of a double singleton pregnancies in a woman with a double uterus, double cervix, and complete septate vagina. J Chin Med Assoc. 2015;78:746–8.CrossRef Yang MJ, Tseng JY, Chen CY, Li HY. Delivery of a double singleton pregnancies in a woman with a double uterus, double cervix, and complete septate vagina. J Chin Med Assoc. 2015;78:746–8.CrossRef
3.
go back to reference Fedele L, Ferrazzi E, Dorta M, Vercellini P, Candiani G. Ultrasonography in the differential diagnosis of ‘double’ uteri. Fertil Steril. 1988;50:361–4.CrossRef Fedele L, Ferrazzi E, Dorta M, Vercellini P, Candiani G. Ultrasonography in the differential diagnosis of ‘double’ uteri. Fertil Steril. 1988;50:361–4.CrossRef
4.
go back to reference Heinonen PK. Clinical implications of the didelphic uterus: long term follow-up of 49 cases. Eur J Obstet Gynecol Reprod Biol. 2000;91:183–90.CrossRef Heinonen PK. Clinical implications of the didelphic uterus: long term follow-up of 49 cases. Eur J Obstet Gynecol Reprod Biol. 2000;91:183–90.CrossRef
5.
go back to reference Grimbizis GF, Camus M, Tarlatzis BC, Bontis JN, Devroey P. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update. 2001;7(2):161–74.CrossRef Grimbizis GF, Camus M, Tarlatzis BC, Bontis JN, Devroey P. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update. 2001;7(2):161–74.CrossRef
6.
go back to reference Pui M. Imaging diagnosis of congenital uterine malformation. Comput Med Imaging Graph. 2004;28(7):425–33.CrossRef Pui M. Imaging diagnosis of congenital uterine malformation. Comput Med Imaging Graph. 2004;28(7):425–33.CrossRef
7.
go back to reference Raga F, Bauset C, Remohi J, Bonilla-Musoles F, Simón C, Pellicer A. Reproductive impact of congenital Müllerian anomalies. Hum Reprod. 1997;12(10):2277–81.CrossRef Raga F, Bauset C, Remohi J, Bonilla-Musoles F, Simón C, Pellicer A. Reproductive impact of congenital Müllerian anomalies. Hum Reprod. 1997;12(10):2277–81.CrossRef
8.
go back to reference Nohara M, Nakayama M, Masamoto H, Nakazato K, Sakumoto K, Kanazawa K. Twin pregnancy in each half of a uterus didelphys with a delivery interval of 66 days. BJOG Int J Obstetr Gynaecol. 2003;110(3):331–2.CrossRef Nohara M, Nakayama M, Masamoto H, Nakazato K, Sakumoto K, Kanazawa K. Twin pregnancy in each half of a uterus didelphys with a delivery interval of 66 days. BJOG Int J Obstetr Gynaecol. 2003;110(3):331–2.CrossRef
9.
go back to reference Lewenthal H, Biale Y, Ben-Adereth N. Uterus didelphys with a pregnancy in each horn. Case report. BJOG Int J Obstetr Gynaecol. 1977;84(2):155–6.CrossRef Lewenthal H, Biale Y, Ben-Adereth N. Uterus didelphys with a pregnancy in each horn. Case report. BJOG Int J Obstetr Gynaecol. 1977;84(2):155–6.CrossRef
10.
go back to reference Rao A, Sairam S, Shehata H. Obstetric complications of twin pregnancies. Best Pract Res Clin Obstet Gynaecol. 2004;18:557–76.CrossRef Rao A, Sairam S, Shehata H. Obstetric complications of twin pregnancies. Best Pract Res Clin Obstet Gynaecol. 2004;18:557–76.CrossRef
11.
go back to reference Gómez E, Ruíz-Alonso M, Miravet J, Simón C. Human endometrial transcriptomics: implications for embryonic implantation. Cold Spring Harb Perspect Med. 2015;5:022996.CrossRef Gómez E, Ruíz-Alonso M, Miravet J, Simón C. Human endometrial transcriptomics: implications for embryonic implantation. Cold Spring Harb Perspect Med. 2015;5:022996.CrossRef
12.
go back to reference Al-Hussaini TK. Two successful pregnancies using split embryo transfer in a woman with uterus didelphys: a case report. Middle East Fertil Soc J. 2016;06:008. Al-Hussaini TK. Two successful pregnancies using split embryo transfer in a woman with uterus didelphys: a case report. Middle East Fertil Soc J. 2016;06:008.
Metadata
Title
Embryo transfer can be performed in either uterine horn. Two successive pregnancies in a patient with uterus didelphys: a case report
Author
Zakwan Khrait
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-021-02884-5

Other articles of this Issue 1/2021

Journal of Medical Case Reports 1/2021 Go to the issue