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Published in: Journal of Medical Case Reports 1/2021

Open Access 01-12-2021 | Hemangioma | Case report

Disseminated intravascular coagulation as a complication of bursitis: angiogenesis and repetitive bleeding as potential factors for disseminated intravascular coagulation: a case report

Authors: Taisuke Hamada, Tasuku Nishihara, Yosuke Mizuno, Teruki Kidani, Hiroki Tokiwa, Naoki Abe, Keisuke Sekiya, Sakiko Kitamura, Yasushi Takasaki, Hiromasa Miura, Toshihiro Yorozuya

Published in: Journal of Medical Case Reports | Issue 1/2021

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Abstract

Background

Malignant tumors, such as acute leukemia and solid cancers, frequently cause disseminated intravascular coagulation. However, cases of disseminated intravascular coagulation as a complication of bursitis were not reported previously.

Case presentation

A 72-year-old Japanese woman was scheduled to undergo resection of a rapidly growing subcutaneous tumor-like lesion on her left back. Preoperative blood tests suggested disseminated intravascular coagulation. The resected lesion was cystic tumor containing a hematoma. After the operation, the patient completely recovered from disseminated intravascular coagulation, indicating that disseminated intravascular coagulation in this case was caused by the tumor. Pathological examination of the resected tumor revealed considerable fibrin deposition and angiogenesis on the cyst wall, which was presumably a response to inflammation and indicated presence of repetitive intratumoral bleeding, subsequently leading to a diagnosis of chronic hemorrhagic bursitis.

Conclusions

Clinicians should note that, despite being benign, soft-tissue tumors accompanied by inflammation with angiogenesis and repetitive intratumoral bleeding can cause disseminated intravascular coagulation, albeit rarely.
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Literature
1.
go back to reference Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999;341(8):586–92.CrossRef Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999;341(8):586–92.CrossRef
2.
go back to reference Asakura H. Classifying types of disseminated intravascular coagulation: clinical and animal models. J Intensive Care. 2014;2(1):20.CrossRef Asakura H. Classifying types of disseminated intravascular coagulation: clinical and animal models. J Intensive Care. 2014;2(1):20.CrossRef
3.
go back to reference Gando S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit Care Med. 2010;38(2 Suppl):S35-42.CrossRef Gando S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit Care Med. 2010;38(2 Suppl):S35-42.CrossRef
4.
go back to reference Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ. 2012;344:e3054.CrossRef Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ. 2012;344:e3054.CrossRef
5.
go back to reference Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br J Haematol. 2009;145(1):24–33.CrossRef Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br J Haematol. 2009;145(1):24–33.CrossRef
6.
go back to reference Di Nisio M, Baudo F, Cosmi B, D’Angelo A, De Gasperi A, Malato A, Schiavoni M, Squizzato A. Italian Society for T, haemostasis: diagnosis and treatment of disseminated intravascular coagulation: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res. 2012;129(5):e177-184.CrossRef Di Nisio M, Baudo F, Cosmi B, D’Angelo A, De Gasperi A, Malato A, Schiavoni M, Squizzato A. Italian Society for T, haemostasis: diagnosis and treatment of disseminated intravascular coagulation: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res. 2012;129(5):e177-184.CrossRef
7.
go back to reference Franchini M, Di Minno MN, Coppola A. Disseminated intravascular coagulation in hematologic malignancies. Semin Thromb Hemost. 2010;36(4):388–403.CrossRef Franchini M, Di Minno MN, Coppola A. Disseminated intravascular coagulation in hematologic malignancies. Semin Thromb Hemost. 2010;36(4):388–403.CrossRef
8.
go back to reference Gilon E, Ramot B, Sheba C. Multiple hemangiomata associated with thrombocytopenia: remarks on the pathogenesis of the thrombocytopenia in this syndrome. Blood. 1959;14(1):74–9.CrossRef Gilon E, Ramot B, Sheba C. Multiple hemangiomata associated with thrombocytopenia: remarks on the pathogenesis of the thrombocytopenia in this syndrome. Blood. 1959;14(1):74–9.CrossRef
9.
go back to reference Seo SK, Suh JC, Na GY, Kim IS, Sohn KR. Kasabach–Merritt syndrome: identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61. Pediatr Dermatol. 1999;16(5):392–4.CrossRef Seo SK, Suh JC, Na GY, Kim IS, Sohn KR. Kasabach–Merritt syndrome: identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61. Pediatr Dermatol. 1999;16(5):392–4.CrossRef
10.
go back to reference Hall GW. Kasabach–Merritt syndrome: pathogenesis and management. Br J Haematol. 2001;112(4):851–62.CrossRef Hall GW. Kasabach–Merritt syndrome: pathogenesis and management. Br J Haematol. 2001;112(4):851–62.CrossRef
Metadata
Title
Disseminated intravascular coagulation as a complication of bursitis: angiogenesis and repetitive bleeding as potential factors for disseminated intravascular coagulation: a case report
Authors
Taisuke Hamada
Tasuku Nishihara
Yosuke Mizuno
Teruki Kidani
Hiroki Tokiwa
Naoki Abe
Keisuke Sekiya
Sakiko Kitamura
Yasushi Takasaki
Hiromasa Miura
Toshihiro Yorozuya
Publication date
01-12-2021

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