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Journal of Medical Case Reports

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Open Access 01-12-2019 | Kidney Cancer | Case report

Low-dose axitinib rechallenge with positive outcomes in a patient with metastatic renal cell carcinoma refractory to interferon α, sunitinib, axitinib, and nivolumab therapies: a case report

Authors: Masaki Murata, Yohei Ikeda, Go Hasegawa, Yuki Nakagawa, Tsutomu Nishiyama

Published in: Journal of Medical Case Reports | Issue 1/2019

Abstract

Background

There is no established treatment after failure of proven therapies for patients with metastatic renal cell carcinoma.

Case presentation

A 66-year-old Japanese man with metastatic renal cell carcinoma became refractory to interferon α and sunitinib therapies. He started treatment with axitinib at 10 mg/day, and the dose was gradually tapered down to 4 mg/day because of intolerable adverse events. His metastatic lesions shrank; however, he could not continue due to the adverse events. He started fourth-line therapy with nivolumab; however, the metastatic lesions increased. Rechallenge with axitinib 4 mg/day was started, and the dose was reduced to 2 mg/day because of adverse events. Subsequently, the adverse events became controllable, and the metastatic lesions were maintained at reduced size.

Conclusion

Therapeutic drug monitoring of axitinib could play an important role in the development of safe and effective therapeutic treatment and individualization of these medications.

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Title: Low-dose axitinib rechallenge with positive outcomes in a patient with metastatic renal cell carcinoma refractory to interferon α, sunitinib, axitinib, and nivolumab therapies: a case report
Authors: Masaki Murata
Yohei Ikeda
Go Hasegawa
Yuki Nakagawa
Tsutomu Nishiyama
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Kidney Cancer
Metastasis
Kidney Cancer
Kidney Cancer
Interferon
Axitinib
Sunitinib
Published in: Journal of Medical Case Reports / Issue 1/2019
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-019-2041-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Low-dose axitinib rechallenge with positive outcomes in a patient with metastatic renal cell carcinoma refractory to interferon α, sunitinib, axitinib, and nivolumab therapies: a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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