Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2019

Open Access 01-12-2019 | Computed Tomography | Case report

Micronodular thymoma with lymphoid stroma diagnosed 10 years after the first operation: a case report

Authors: Yasunori Kaminuma, Masayuki Tanahashi, Haruhiro Yukiue, Eriko Suzuki, Naoko Yoshii, Toshio Fujino, Hiroshi Ogawa, Hiroshi Niwa

Published in: Journal of Medical Case Reports | Issue 1/2019

Login to get access

Abstract

Introduction

Micronodular thymoma with lymphoid stroma is a rare subtype of thymoma. Here we report a case of micronodular thymoma with lymphoid stroma that was completely resected after incomplete resection 10 years earlier.

Case presentation

A 70-year-old Japanese woman who had undergone resection for a thymic cyst 10 years earlier was found to have a solid nodule with a multilocular lesion at the site of the previous operation. We suspected that the tumor was a malignant tumor and performed trans-sternal radical thymectomy and diagnosed the lesion as micronodular thymoma with lymphoid stroma pathologically. When we reassessed the thymic cyst that had been resected 10 years earlier, a few lesions of micronodular thymoma with lymphoid stroma were found in the cyst wall. Based on these findings, we concluded that only the cystic component of micronodular thymoma with lymphoid stroma had been removed, and that the residual lesion grew locally over the next 10 years before being completely resected by reoperation.

Conclusion

We experienced an unusual case of micronodular thymoma with lymphoid stroma, which is a rare subtype of thymoma. Greater care should be taken to exclude a thymoma with a cystic lesion, even if a thymic cyst is strongly suspected on computed tomography and magnetic resonance imaging.
Literature
1.
go back to reference Tateyama H, Girard N, Marx A, Marchevsky AM, Ströbel P, Marom EM, Detterbeck F, Mukai K. Micronodular thymoma with lymphoid stroma. In: Travis WD, Brambilla E, Nicholson AG, editors. WHO classification of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: World Health Organization; 2015. p. 205–6. Tateyama H, Girard N, Marx A, Marchevsky AM, Ströbel P, Marom EM, Detterbeck F, Mukai K. Micronodular thymoma with lymphoid stroma. In: Travis WD, Brambilla E, Nicholson AG, editors. WHO classification of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: World Health Organization; 2015. p. 205–6.
2.
go back to reference Suster S, Moran CA. Micronodular Thymoma With Lymphoid B-cell Hyperplasia: Clinicopathologic and Immunohistochemical Study of Eighteen Cases of a Distinctive Morphologic Variant of Thymic Epithelial Neoplasm. Am J Surg Pathol. 1999;23:955–62.CrossRef Suster S, Moran CA. Micronodular Thymoma With Lymphoid B-cell Hyperplasia: Clinicopathologic and Immunohistochemical Study of Eighteen Cases of a Distinctive Morphologic Variant of Thymic Epithelial Neoplasm. Am J Surg Pathol. 1999;23:955–62.CrossRef
3.
go back to reference Mneimneh WS, Gökmen-Polar Y, Kesler KA, Loehrer PJ Sr, Badve S. Micronodular thymic neoplasms: case series and literature review with emphasis on the spectrum of differentiation. Mod Pathol. 2015;28:1415–27.CrossRef Mneimneh WS, Gökmen-Polar Y, Kesler KA, Loehrer PJ Sr, Badve S. Micronodular thymic neoplasms: case series and literature review with emphasis on the spectrum of differentiation. Mod Pathol. 2015;28:1415–27.CrossRef
4.
go back to reference Ströbel P, Marino M, Feuchtenberger M, Rouzière AS, Tony HP, Wulbrand U, et al. Micronodular thymoma: an epithelial tumour with abnormal chemokine expression setting the stage for lymphoma development. J Pathol. 2005;207:72–82.CrossRef Ströbel P, Marino M, Feuchtenberger M, Rouzière AS, Tony HP, Wulbrand U, et al. Micronodular thymoma: an epithelial tumour with abnormal chemokine expression setting the stage for lymphoma development. J Pathol. 2005;207:72–82.CrossRef
5.
go back to reference Oda R, Mizuno K, Sakane T, Matsui T, Yamada T. A case of micronodular thymoma with lymphoid stroma. Jpn J Chest Surg. 2014;28:795–9. (in Japanese)CrossRef Oda R, Mizuno K, Sakane T, Matsui T, Yamada T. A case of micronodular thymoma with lymphoid stroma. Jpn J Chest Surg. 2014;28:795–9. (in Japanese)CrossRef
6.
go back to reference Tahara S, Takami K, Omiya H, Kuriyama K, Kodama Y, Tsujinaka T. Micronodular Thymoma with Lymphoid Stroma (MNT). Kyobu Geka. 2012;65:1045–8. (in Japanese)PubMed Tahara S, Takami K, Omiya H, Kuriyama K, Kodama Y, Tsujinaka T. Micronodular Thymoma with Lymphoid Stroma (MNT). Kyobu Geka. 2012;65:1045–8. (in Japanese)PubMed
Metadata
Title
Micronodular thymoma with lymphoid stroma diagnosed 10 years after the first operation: a case report
Authors
Yasunori Kaminuma
Masayuki Tanahashi
Haruhiro Yukiue
Eriko Suzuki
Naoko Yoshii
Toshio Fujino
Hiroshi Ogawa
Hiroshi Niwa
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2019
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-019-2006-y

Other articles of this Issue 1/2019

Journal of Medical Case Reports 1/2019 Go to the issue