Top

Published in:

Open Access 01-12-2017 | Case report

Adenoid cystic carcinoma of the breast – an aggressive presentation with pulmonary, kidney, and brain metastases: a case report

Authors: Hasnae Alaoui Mhamdi, Hampig Raphael Kourie, Christiane Jungels, Philippe Aftimos, Rhizlane Belbaraka, Martine Piccart-Gebhart

Published in: Journal of Medical Case Reports | Issue 1/2017

Abstract

Background

Adenoid cystic carcinoma of the breast is a rare malignant neoplasm associated with an excellent prognosis and a very rare occurrence of metastases.

Case presentation

We report the case of an aggressive presentation in a 65-year-old woman, of Belgian origin, who was diagnosed as having adenoid cystic carcinoma of the breast and developed metastases to her lung, kidney, and brain.

Conclusions

We describe similar cases reported in the literature and discuss the molecular characteristics and treatment paradigm of this controversially aggressive disease entity.

Coca-Pelaz A, Rodrigo JP, Bradley PJ. Adenoid cystic carcinoma of the head and neck – An update. Oral Oncol. 2015;51(7):652–61.CrossRefPubMed

Kim M, Lee DW, Im J, Suh KJ, Keam B, Moon HG, et al. Adenoid Cystic Carcinoma of the Breast: A Case Series of Six Patients and Literature Review. Cancer Res Treat. 2014;46(1):93–7.CrossRefPubMedPubMedCentral

Senger JL, Kanthan R. Adenoid Cystic Carcinoma of the Breast A Focused Review. JSM Surg Oncol Res. 2016;1(2):1008.

Canyilmaz E, Hanedan Ulsu G, Memis Y. Adenoid cystic carcinoma of the breast: A case report and literature review. Oncol Lett. 2014;7(5):1599–601.PubMedPubMedCentral

Miyai K, Schwartz MR, Divatia MK, Anton RC, Park WR, Ayala AG, Ro J. Adenoid cystic carcinoma of breast: Recent advances. World J Clin Cases. 2014;2(12):732–41.CrossRefPubMedPubMedCentral

Arpino G, Clark GM, Mohsen S, et al. Adenoid cystic carcinoma of the breast. Molecular markers, treatment and clinical outcome. Cancer. 2002;94:2119–17.CrossRefPubMed

Kulkarni N, Pezzi CM, Greif JM, et al. Rare breast cancer: 933 Adenoid cystic carcinomas from the national cancer data base. Ann Surg Oncol. 2013;20(7):2236–41.CrossRefPubMed

Boujelbene N, Khabir A, Boujelbene N, et al. Clinical review – breast adenoid cystic carcinoma. Breast. 2012;21(2):124–7.CrossRefPubMed

Herzberg AJ, Bossen EH, Walther PJ, et al. Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management. Cancer. 1991;68(5):1015–20.CrossRefPubMed

10.

Vranic S, Bilalovic N, Lee L, et al. PI3K3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. Hum Pathol. 2007;38(9):1425–31.CrossRefPubMed

11.

Koller M, Ram Z, Findler G, et al. Brain Metastasis: A rare manifestation of adenoid cystic carcinoma of the breast. Surg Neurol. 1986;26(5):470–2.CrossRefPubMed

12.

Silva I, Tome V, Oliveira J. Adenoid cystic carcinoma of the breast with cerebral metastisation: a clinical novelty. BMJ. 2011;2011. doi:10.1136/bcr.08.2011.4692.

13.

Coates JM, Martinez SR, Bold RJ, et al. Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast. J Surg Onco. 2010;102(4):342–7.CrossRef

14.

Khanfir K, Kallel A, Villette S, Belkacémi Y, et al. Management of adenoid cystic carcinoma of the breast: a Rare Cancer Network study. Int J Radiat Onco. 2012;82(5):2118–24.CrossRef

15.

Ghabach B, Anderson WF, Curtis RE, et al. Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study. Breast Cancer Res. 2010;12(4):R54.CrossRefPubMedPubMedCentral

16.

Mattox DE, Von Hoff DD, Balcerzak SP. Southwest Oncology Group study of mitoxantrone for treatment of patients with advanced adenoid cystic carcinoma of the head and neck. Invest New Drugs. 1990;8(1):105–7.CrossRefPubMed

17.

Verweij J, Mulder PH, De Graeff A, et al. Phase II study on mitoxantrone in adenoid cystic carcinoma of the head and neck. EORTC Head and Neck Cancer Cooperative Group. Ann Oncol. 1996;7(8):867–9.CrossRefPubMed

Title: Adenoid cystic carcinoma of the breast – an aggressive presentation with pulmonary, kidney, and brain metastases: a case report
Authors: Hasnae Alaoui Mhamdi
Hampig Raphael Kourie
Christiane Jungels
Philippe Aftimos
Rhizlane Belbaraka
Martine Piccart-Gebhart
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2017
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-017-1459-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Adenoid cystic carcinoma of the breast – an aggressive presentation with pulmonary, kidney, and brain metastases: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2017

Remarkable response to fluorouracil, leucovorin, oxaliplatin, and irinotecan therapy in urothelial cancer of the renal pelvis: a case report

How to choose the best journal for your case report

Rare presentation of intractable tuberculous panophthalmitis with intraocular and intraorbital abscesses: a case report

Epoetin β pegol (continuous erythropoietin receptor activator, CERA) is another choice for the treatment of anemia in myelodysplastic syndrome: a case report

Bilateral multiple pulmonary artery aneurysms associated with cavitary pulmonary tuberculosis: a case report

Chemotherapy for primary mediastinal yolk sac tumor in a patient undergoing chronic hemodialysis: a case report