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Journal of Medical Case Reports

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Open Access 01-12-2017 | Case report

Gamma-delta (γδ) T-cell lymphoma – another case unclassifiable by World Health Organization classification: a case report

Authors: Hemant Sindhu, Ruqin Chen, Hui Chen, Jonathan Wong, Rashid Chaudhry, Yin Xu, Jen C. Wang

Published in: Journal of Medical Case Reports | Issue 1/2017

Abstract

Background

We present a case of gamma-delta T-cell lymphoma that does not fit the current World Health Organization classifications.

Case presentation

A 74-year-old Caribbean-American woman presented with lymphocytosis, pruritus, and non-drenching night sweats. Bone marrow and peripheral blood analyses both confirmed the diagnosis of gamma-delta T-cell lymphoma. An axillary lymph node biopsy was negative for lymphoma. Clinically absent hepatosplenomegaly and skin lesions with biopsy-proven gamma-delta T-cell lymphoma suggest that she is unclassifiable within the current classification system.

Conclusions

We believe this is a case of not otherwise specified gamma-delta T-cell lymphoma. Accumulation of these rare not otherwise specified cases will be important for future classification which further defines the biology of this disease.

Bordessoule D, Gaulard P, Mason DY. Preferential localisation of human lymphocytes bearing gamma delta T cell receptors to the red pulp of the spleen. J Clin Pathol. 1990;43:461–4.CrossRefPubMedCentralPubMed

Toro JR, Liewehr DJ, Pabby N, Sorbara L, Raffeld M, Steinberg SM, et al. Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. Blood. 2003;101:3407–12.CrossRefPubMed

Swerdlow SH. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: International Agency for Research on Cancer; 2008. Print.

Tripodo C, Iannitto E, Florena AM, et al. Gamma-delta T-cell lymphomas. Nat Rev Clin Oncol. 2009;6(12):707–17.CrossRefPubMed

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Hielmini M, Salles GA, Zelenetz AD, Jaffe ES. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–90.CrossRefPubMedCentralPubMed

Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26(25):4124–30.CrossRefPubMed

Gaulard P, Belhadj K, Reyes F. Gammadelta T-cell lymphomas. Semin Hematol. 2003;40(3):233–43.CrossRefPubMed

Takahashi Y, Takata K, Kato S, Sato Y, Asano N, Ogino T, et al. Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of the γδ phenotype from Japan. Cancer Sci. 2014;105(7):912–23.CrossRefPubMedCentralPubMed

Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, Wolf-Peters CD, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DJ, Müller-Hermelink HK, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA. A revised European-American classification of lymphoid neoplasms. A proposal from the International Lymphoma Study Group. Blood. 1994;84:1361–92.PubMed

10.

Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor–CD3 complex. Molecular immunology. 2004;40(18):1295–305.

11.

Denning SM, Haynes BF. Differentiation of human T cells. Clin Lab Med. 1988;8:1–14.PubMed

12.

Petrie HT, Scollay R, Shortman K. Commitment to the T cell receptor-alpha beta or gamma delta lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes. Eur J Immunol. 1992;22:2185–8.CrossRefPubMed

13.

Foppoli M, Ferreri AJM. Gamma-delta T-cell Lymphomas. Eur J Haematol. 2014;3:206–18.

14.

Travert M, Huang Y, de Leval L, et al. Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets. Blood. 2012;119:5795–806.CrossRefPubMedCentralPubMed

15.

Ozaki S, Ogasahara K, Kosaka M, Inoshita T, Wakatsuki S, Uehara H, Matsumoto T. Hepatosplenic gamma delta T-cell lymphoma associated with hepatitis B virus infection. J Med Invest. 1998;44:215–7.PubMed

16.

Iannitto E, Tripodo C. How I diagnose and treat splenic lymphomas. Blood. 2011;117:2585–95.CrossRefPubMed

17.

Ashmore P, Patel M, Vaughan J, et al. Hepatosplenic T-cell lymphoma: a case series. Hematol Oncol Stem Cell Ther. 2014

18.

Falchook GS, Vega F, Dang NH, et al. Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment. Ann Oncol. 2009;20(6):1080–5.CrossRefPubMedCentralPubMed

Title: Gamma-delta (γδ) T-cell lymphoma – another case unclassifiable by World Health Organization classification: a case report
Authors: Hemant Sindhu
Ruqin Chen
Hui Chen
Jonathan Wong
Rashid Chaudhry
Yin Xu
Jen C. Wang
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2017
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-017-1312-5

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Gamma-delta (γδ) T-cell lymphoma – another case unclassifiable by World Health Organization classification: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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