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Published in: Journal of Medical Case Reports 1/2016

Open Access 01-12-2016 | Case report

Classic Kaposi’s sarcoma - complete response to radiation therapy: a case report

Authors: Kennet Ramírez, José Zavala, David Morán, Diana Hernández, Alberto Jiménez

Published in: Journal of Medical Case Reports | Issue 1/2016

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Abstract

Background

Classic Kaposi’s sarcoma is a lymphatic endothelial cell neoplasm usually present on the skin of the upper and lower extremities. Although it commonly affects human immunodeficiency virus positive patients, there have been some human immunodeficiency virus negative cases reported. We report an uncommon presentation of stage IV classic Kaposi’s sarcoma in an human immunodeficiency virus negative patient in Latin America with complete clinical response using only radiation therapy treatment.

Case presentation

A 78-year-old Mexican man with no evidence of human immunodeficiency virus infection presented with a painful widespread dermatosis with maculopapular, nodular, violaceous lesions on his legs and ulcerated lesions on his feet. A biopsy confirmed the lesions as classic Kaposi’s sarcoma. Radiotherapy treatment was delivered, prescribing a total dose of 30 Gy in 15 fractions with a complete clinical response within 15 months of follow-up.

Conclusions

This is an unusual case since it is uncommon to use radiation therapy as the single treatment in stage IV classic Kaposi’s sarcoma; the efficacy of the treatment is shown in the impact in our patient’s recurrence-free survival, local control, and palliation of our patient’s symptoms.
Literature
1.
go back to reference Szajerka T, Jablecki J. Kaposi’s sarcoma revisited. AIDS Rev. 2007;9:230–6.PubMed Szajerka T, Jablecki J. Kaposi’s sarcoma revisited. AIDS Rev. 2007;9:230–6.PubMed
2.
go back to reference Sullivan RJ, Pantanowitz L, Casper C, Stebbing J, Dezube BJ. HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Clin Infect Dis. 2008;47(9):1209–15.CrossRefPubMedPubMedCentral Sullivan RJ, Pantanowitz L, Casper C, Stebbing J, Dezube BJ. HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Clin Infect Dis. 2008;47(9):1209–15.CrossRefPubMedPubMedCentral
3.
4.
go back to reference Rojo DE. Armando: Acta Medica Grupo Angeles, Sarcoma de Kaposi; resumen 11, No 1 enero-marzo. 2013 Rojo DE. Armando: Acta Medica Grupo Angeles, Sarcoma de Kaposi; resumen 11, No 1 enero-marzo. 2013
5.
go back to reference Iscovich J, Boffetta P, Winkelmann R, Brennan P. Classic Kaposi’s sarcoma as a second primary neoplasm. Int J Cancer. 1999;80:178–82.CrossRefPubMed Iscovich J, Boffetta P, Winkelmann R, Brennan P. Classic Kaposi’s sarcoma as a second primary neoplasm. Int J Cancer. 1999;80:178–82.CrossRefPubMed
6.
go back to reference Brambilla L, Boneschi V, Taglioni M, Ferrucci S. Staging of classic Kaposi’s sarcoma: a useful tool for therapeutic choices. Eur J Dermatol. 2003;13(1):83–6.PubMed Brambilla L, Boneschi V, Taglioni M, Ferrucci S. Staging of classic Kaposi’s sarcoma: a useful tool for therapeutic choices. Eur J Dermatol. 2003;13(1):83–6.PubMed
7.
go back to reference Cooper JS, Steinfeld AD, Lerch I. Intentions and outcomes in the radiotherapeutic management of epidemic Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys. 1991;20(3):419–22.CrossRefPubMed Cooper JS, Steinfeld AD, Lerch I. Intentions and outcomes in the radiotherapeutic management of epidemic Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys. 1991;20(3):419–22.CrossRefPubMed
8.
go back to reference Akmansu M, Goksel F, Erpolat OP, Unsal D, Karahacioglu E, Bora H. The palliative radiotherapy of classic Kaposi’s sarcoma of foot region: retrospective evaluation. Int J Hematol Oncol. 2014;24:147–52. Akmansu M, Goksel F, Erpolat OP, Unsal D, Karahacioglu E, Bora H. The palliative radiotherapy of classic Kaposi’s sarcoma of foot region: retrospective evaluation. Int J Hematol Oncol. 2014;24:147–52.
9.
go back to reference Nicolini G, Abraham S, Fogliata A, Jordaan A, Clivio A, Vanetti E, Cozzi L. Critical appraisal of volumetric-modulated arc therapy compared with electrons for the radiotherapy of cutaneous Kaposi’s sarcoma of lower extremities with bone sparing. Br J Radiol. 2013;86:20120543.CrossRefPubMedPubMedCentral Nicolini G, Abraham S, Fogliata A, Jordaan A, Clivio A, Vanetti E, Cozzi L. Critical appraisal of volumetric-modulated arc therapy compared with electrons for the radiotherapy of cutaneous Kaposi’s sarcoma of lower extremities with bone sparing. Br J Radiol. 2013;86:20120543.CrossRefPubMedPubMedCentral
10.
go back to reference Singh NB, Lakier RH, Donde B. Hypofractionated radiation therapy in the treatment of epidemic Kaposi sarcoma--a prospective randomized trial. Radiother Oncol. 2008;88(2):211–6.CrossRefPubMed Singh NB, Lakier RH, Donde B. Hypofractionated radiation therapy in the treatment of epidemic Kaposi sarcoma--a prospective randomized trial. Radiother Oncol. 2008;88(2):211–6.CrossRefPubMed
11.
go back to reference Harrison M, Harrington KJ, Tomlinson DR, Stewart JS. Response and cosmetic outcome of two fractionation regimens for AIDS-related Kaposi’s sarcoma. Radiother Oncol. 1998;46(1):23–8.CrossRefPubMed Harrison M, Harrington KJ, Tomlinson DR, Stewart JS. Response and cosmetic outcome of two fractionation regimens for AIDS-related Kaposi’s sarcoma. Radiother Oncol. 1998;46(1):23–8.CrossRefPubMed
Metadata
Title
Classic Kaposi’s sarcoma - complete response to radiation therapy: a case report
Authors
Kennet Ramírez
José Zavala
David Morán
Diana Hernández
Alberto Jiménez
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2016
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-016-1101-6

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