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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2016

Open Access 01-12-2016 | Case report

Oral mucosal melanoma treated with carbon ion radiotherapy: a case report

Authors: Atsushi Musha, Jun-ichi Saitoh, Katsuyuki Shirai, Satoshi Yokoo, Tatsuya Ohno, Takashi Nakano

Published in: Journal of Medical Case Reports | Issue 1/2016

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Abstract

Background

Oral mucosal melanoma is a rare disease with a relatively poor prognosis. Carbon ion radiotherapy has been shown to be effective against radiotherapy-resistant tumors owing to its excellent dose concentration and high biological effect.

Case presentation

Our patient was a 66-year-old Japanese man with oral mucosal melanoma of his right maxillary gingiva (T4aN0M0). He received carbon ion radiotherapy at 57.6 Gy (relative biological effectiveness) in 16 fractions for 4 weeks. Concomitant chemotherapy (dacarbazine + nimustine + vincristine) was administered at the same time as carbon ion radiotherapy initiation. Two courses of adjuvant chemotherapy were given after carbon ion radiotherapy. Although he experienced grade 2 acute oral mucositis, his symptoms improved within a few weeks of undergoing carbon ion radiotherapy. He was alive at the time of reporting, 35 months after treatment, without any recurrence. Late toxicity has not been observed.

Conclusions

Carbon ion radiotherapy for oral mucosal melanoma resulted in a good local effect.
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Metadata
Title
Oral mucosal melanoma treated with carbon ion radiotherapy: a case report
Authors
Atsushi Musha
Jun-ichi Saitoh
Katsuyuki Shirai
Satoshi Yokoo
Tatsuya Ohno
Takashi Nakano
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2016
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-016-1071-8

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