Top

Published in:

Open Access 01-12-2016 | Case report

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report

Authors: Mari Ohtaka, Takashi Kawahara, Yohei Kumano, Yoko Maeda, Takuya Kondo, Taku Mochizuki, Hiroaki Ishida, Yusuke Hattori, Jun-ichi Teranishi, Yasuhide Miyoshi, Yasushi Yumura, Masahiro Yao, Yoshiaki Inayama, Hiroji Uemura

Published in: Journal of Medical Case Reports | Issue 1/2016

Abstract

Background

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.

Case presentation

A 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the bladder tumor revealed pT1N0M0 bladder cancer. A pathological examination showed high-grade invasive urothelial carcinoma and a component of signet ring cell carcinoma. A follow-up of the transurethral resection with radical cystectomy was carried out, and a pathological examination showed infiltrating urothelial carcinoma, with partial features of the plasmacytoid variant. We added chemotherapy treatment with gemcitabine and cisplatin for two cycles. Our patient has been free from recurrence for 2 years.

Conclusions

We herein report the case of a patient with a plasmacytoid variant of urothelial carcinoma controlled with radial cystectomy and subsequent chemotherapy.

Wang Z, Lu T, Du L, Hu Z, Zhuang Q, Li Y, et al. Plasmacytoid urothelial carcinoma of the urinary bladder: a clinical pathological study and literature review. Int J Clin Exp Pathol. 2012;5:601–8.PubMedPubMedCentral

Keck B, Stoehr R, Wach S, Rogler A, Hofstaedter F, Lehmann J, et al. The plasmacytoid carcinoma of the bladder--rare variant of aggressive urothelial carcinoma. Int J Cancer. 2011;129:346–54.CrossRefPubMed

Gonzalez-Roibon ND, Chaux A, Al-Hussain T, Osunkoya AO, Bezerra SM, Hicks J, et al. Dysregulation of mammalian target of rapamycin pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder. Hum Pathol. 2013;44:612–22.CrossRefPubMedPubMedCentral

Qin M, Wang G, Sun Y, He Q. Plasmacytoid urothelial carcinoma of the bladder. Indian J Pathol Microbiol. 2014;57:320–2.CrossRefPubMed

Sahin AA, Myhre M, Ro JY, Sneige N, Dekmezian RH, Ayala AG. Plasmacytoid transitional cell carcinoma. Report of a case with initial presentation mimicking multiple myeloma. Acta Cytol. 1991;35:277–80.PubMed

Kawahara T, Oshiro H, Sekiguchi Z, Ito H, Makiyama K, Uemura H, et al. High-grade invasive urothelial carcinoma with focal plasmacytoid differentiation successfully treated by transurethral resection followed by chemoradiotherapy. Int J Urol. 2011;18:851–3.CrossRefPubMed

Keck B, Wach S, Stoehr R, Kunath F, Bertz S, Lehmann J, et al. Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy. BMC Cancer. 2013;13:71.CrossRefPubMedPubMedCentral

Kaimakliotis HZ, Monn MF, Cary KC, Pedrosa JA, Rice K, Masterson TA, et al. Plasmacytoid variant urothelial bladder cancer: is it time to update the treatment paradigm? Urol Oncol. 2014;32:833–8.CrossRefPubMed

Kaimakliotis HZ, Monn MF, Cheng L, Masterson TA, Cary KC, Pedrosa JA, et al. Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes. Urology. 2014;83:1112–6.CrossRefPubMed

10.

Brower V. Anti-PD-L1 antibody active in metastatic bladder cancer. Lancet Oncol. 2015;16:e11.CrossRefPubMed

11.

Boorjian SA, Sheinin Y, Crispen PL, Farmer SA, Lohse CM, Kuntz SM, et al. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin Cancer Res. 2008;14:4800–8.CrossRefPubMed

12.

Kohno T, Kitamura M, Akai H, Takaha M, Kawahara K, Oka T: Plasmacytoid urothelial carcinoma of the bladder. Int J Urol 2006, 13(4):485–486.CrossRefPubMed

13.

Kawashima A, Ujike T, Nin M, Nishimura K, Miyoshi S: [Plasmacytoid urothelial carcinoma of the bladder: a case report]. Nihon Hinyokika Gakkai Zasshi 2009, 100(5):590–594.PubMed

14.

Fritsche HM, Burger M, Denzinger S, Legal W, Goebell PJ, Hartmann A: Plasmacytoid urothelial carcinoma of the bladder: histological and clinical features of 5 cases. J Urol 2008, 180(5):1923–1927.CrossRefPubMed

15.

Soylu A, Aydin NE, Yilmaz U, Kutlu R, Gunes A: Urothelial carcinoma featuring lipid cell and plasmacytoid morphology with poor prognostic outcome. Urology 2005, 65(4):797.CrossRefPubMed

16.

Aldousari S, Sircar K, Kassouf W: Plasmacytoid urothelial carcinoma of the bladder: a case report. Cases J 2009, 2:6647.CrossRefPubMedPubMedCentral

17.

Hayashi T, Tanigawa G, Fujita K, Imamura R, Nakazawa S, Yamamoto Y, Hosomi M, Shimazu K, Fushimi H, Yamaguchi S: Two cases of plasmacytoid variant of urothelial carcinoma of urinary bladder: systemic chemotherapy might be of benefit. Int J Clin Oncol 2011, 16(6):759–762.CrossRefPubMed

Title: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report
Authors: Mari Ohtaka
Takashi Kawahara
Yohei Kumano
Yoko Maeda
Takuya Kondo
Taku Mochizuki
Hiroaki Ishida
Yusuke Hattori
Jun-ichi Teranishi
Yasuhide Miyoshi
Yasushi Yumura
Masahiro Yao
Yoshiaki Inayama
Hiroji Uemura
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2016
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-016-0806-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2016

Early-onset fetal growth restriction treated with the long-acting phosphodiesterase-5 inhibitor tadalafil: a case report

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

Compression of the peroneal nerve by a neurofibroma originating from collaterals of the peroneal nerve: a case report

Imipenem-cilastatin-induced psychosis: a case report

Medication-induced acute esophageal necrosis: a case report

Epithelioid sarcoma with multiple lesions on the left arm: a case report