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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2015

Open Access 01-12-2015 | Case report

Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review

Authors: Amaiak Chilingaryan, Richard A. Rison, Said R. Beydoun

Published in: Journal of Medical Case Reports | Issue 1/2015

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Abstract

Introduction

Sporadic inclusion body myositis is the most common adult myopathy in persons aged 50 years and older. The clinical presentation includes a chronic, slowly progressive course with a predilection for weakness of the forearm flexors and quadriceps muscles. Its indolent course makes it a disease frequently missed or misdiagnosed as other neuromuscular conditions by health care professionals. The degenerative processes with amyloid accumulation distinguish sporadic inclusion body myositis from other inflammatory myopathies. Currently, no effective therapy exists. This clinical report highlights the difficulties in diagnosing the disease, examples of misdiagnosis, and inappropriate therapies that can result from misdiagnosis.

Case presentation

We present our clinical experience with 20 patients over a 10-year period and describe in depth two cases, both men, one of Indian ethnicity and the other of Hispanic ethnicity, who were referred to our neuromuscular division for second opinions and diagnosed with sporadic inclusion body myositis years after symptom onset.

Conclusions

Although sporadic inclusion body myositis is rare and without effective therapy, accurate diagnosis is crucial to providing adequate counseling and information about the prognosis and disease course, and to avoiding inappropriate therapy.
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Metadata
Title
Misdiagnosis of inclusion body myositis: two case reports and a retrospective chart review
Authors
Amaiak Chilingaryan
Richard A. Rison
Said R. Beydoun
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2015
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-015-0647-z

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