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01-08-2012 | Original Article

A dysphagia study in patients with sporadic inclusion body myositis (s-IBM)

Authors: Ken-ya Murata, Ken Kouda, Fumihiro Tajima, Tomoyoshi Kondo

Published in: Neurological Sciences | Issue 4/2012

Abstract

The nature of the swallowing impairment in patients with sporadic inclusion body myositis (s-IBM) has not been well characterized. In this study, we examined ten consecutive s-IBM patients using videofluoroscopy (VF) and computed pharyngoesophageal manometry (CPM). The patients were divided into two groups: patients with complaint and without complaint of dysphagia. VF results indicated pharyngeal muscle propulsion (PP) at the hypopharyngeal and upper esophagus sphincter (UES) in all s-IBM patients. Patients without complaint of dysphagia showed a mild degree of PP, whereas a severe form of PP was observed in patients with complaint of dysphagia. CPM revealed that negative pressure during UES opening was not observed in the s-IBM patients with complaint of dysphagia. Incomplete opening and PP at the UES were observed in all s-IBM patients. These results indicate that the dysphagic processes occur subclinically in s-IBM patients who may not report swallowing impairments.

Lotz BP, Engel AG, Nishino H, Stevens JC, Litchy WJ (1989) Inclusion body myositis. Observations in 40 patients. Brain 112(Pt 3):727–747PubMedCrossRef

Houser SM, Calabrese LH, Strome M (1998) Dysphagia in patients with inclusion body myositis. Laryngoscope 108:1001–1005PubMedCrossRef

Wintzen AR, Bots GT, de Bakker HM, Hulshof JH, Padberg GW (1988) Dysphagia in inclusion body myositis. J Neurol Neurosurg Psychiatry 51:1542–1545PubMedCrossRef

Danon MJ, Friedman M (1989) Inclusion body myositis associated with progressive dysphagia: treatment with cricopharyngeal myotomy. Can J Neurol Sci 16:436–438PubMed

Dietz F, Logeman JA, Sahgal V, Schmid FR (1980) Cricopharyngeal muscle dysfunction in the differential diagnosis of dysphagia in polymyositis. Arthritis Rheum 23:491–495PubMedCrossRef

Kagen LJ, Hochman RB, Strong EW (1985) Cricopharyngeal obstruction in inflammatory myopathy (polymyositis/dermatomyositis). Report of three cases and review of the literature. Arthritis Rheum 28:630–636PubMedCrossRef

Griggs RC, Askanas V, DiMauro S, Engel A, Karpati G, Mendell JR, Rowland LP (1995) Inclusion body myositis and myopathies. Ann Neurol 38:705–713PubMedCrossRef

Rosenbek JC, Robbins JA, Roecker EB, Coyle JL, Wood JL (1996) A penetration-aspiration scale. Dysphagia 11:93–98PubMedCrossRef

Seaman WB (1966) Cineroentgenographic observations of the cricopharyngeus. Am J Roentgenol Radium Ther Nucl Med 96:922–931PubMed

10.

Kornblum C, Broicher R, Walther E, Seibel P, Reichmann H, Klockgether T, Herberhold C, Schroder R (2001) Cricopharyngeal achalasia is a common cause of dysphagia in patients with mtDNA deletions. Neurology 56:1409–1412PubMedCrossRef

11.

Shapiro J, Martin S, DeGirolami U, Goyal R (1996) Inflammatory myopathy causing pharyngeal dysphagia: a new entity. Ann Otol Rhinol Laryngol 105:331–335PubMed

12.

Cook IJ, Blumbergs P, Cash K, Jamieson GG, Shearman DJ (1992) Structural abnormalities of the cricopharyngeus muscle in patients with pharyngeal (Zenker’s) diverticulum. J Gastroenterol Hepatol 7:556–562PubMedCrossRef

13.

Verma A, Bradley WG, Adesina AM, Sofferman R, Pendlebury WW (1991) Inclusion body myositis with cricopharyngeus muscle involvement and severe dysphagia. Muscle Nerve 14:470–473PubMedCrossRef

14.

Suzuki N, Aoki M, Mori-Yoshimura M, Hayashi YK, Nonaka I, Nishino I (2011) Increase in number of sporadic inclusion body myositis (sIBM) in Japan. J Neurol. doi:10.1007/s00415-011-6185-8

15.

St Guily JL, Moine A, Perie S, Bokowy C, Angelard B, Chaussade S (1995) Role of pharyngeal propulsion as an indicator for upper esophageal sphincter myotomy. Laryngoscope 105:723–727PubMedCrossRef

16.

Cherin P, Pelletier S, Teixeira A, Laforet P, Simon A, Herson S, Eymard B (2002) Intravenous immunoglobulin for dysphagia of inclusion body myositis. Neurology 58:326PubMedCrossRef

17.

Liu LW, Tarnopolsky M, Armstrong D (2004) Injection of botulinum toxin A to the upper esophageal sphincter for oropharyngeal dysphagia in two patients with inclusion body myositis. Can J Gastroenterol 18:397–399PubMed

Title: A dysphagia study in patients with sporadic inclusion body myositis (s-IBM)
Authors: Ken-ya Murata
Ken Kouda
Fumihiro Tajima
Tomoyoshi Kondo
Publication date: 01-08-2012
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 4/2012
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-011-0814-y

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A dysphagia study in patients with sporadic inclusion body myositis (s-IBM)

Abstract

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Abstract

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