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Insights into Imaging

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Open Access 01-12-2020 | Original Article

The effect of the MR pulse sequence on the regional corpus callosum morphometry

Authors: Fahad H. Alhazmi, Osama M. Abdulaal, Abdulaziz A. Qurashi, Khalid M. Aloufi, Vanessa Sluming

Published in: Insights into Imaging | Issue 1/2020

Abstract

Background and purposes

Brain morphometry is an important assessment technique to assess certain morphological brain features of various brain regions, which can be quantified in vivo by using high-resolution structural magnetic resonance (MR) imaging. This study aims to investigate the effect of different types of pulse sequence on regional corpus callosum (CC) morphometry analysis.

Materials and methods

Twenty-one healthy volunteers were scanned twice on the same 3T MRI scanner (Magnetom Trio, Siemens, Erlangen, Germany) equipped with an 8-channel head coil. Two different MR pulse sequences were applied to acquire high-resolution 3D T1-weighted images: magnetization-prepared rapid gradient-echo (MP-RAGE) and modified driven equilibrium Fourier transform (MDEFT) pulse sequence. Image quality measurements such as SNR, contrast-to-noise ratio, and relative contrast were calculated for each pulse sequence images independently. The values of corpus callosum volume were calculated based on the vertex of reconstructed surfaces. The paired dependent t test was applied to compare the means of two matched groups.

Results

Three sub-regional CC, namely anterior, mid-anterior, and posterior, resulted in an estimated volume difference between MDEFT and MP-RAGE pulse sequences. Central and mid-posterior sub-regional CC volume resulted in not significant difference between the two named pulse sequences.

Conclusion

The findings of this study demonstrate that combining data from different pulse sequences in a multisite study could make some variations in the results.

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Title: The effect of the MR pulse sequence on the regional corpus callosum morphometry
Authors: Fahad H. Alhazmi
Osama M. Abdulaal
Abdulaziz A. Qurashi
Khalid M. Aloufi
Vanessa Sluming
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Published in: Insights into Imaging / Issue 1/2020
Electronic ISSN: 1869-4101
DOI: https://doi.org/10.1186/s13244-019-0821-8

At a glance: The STEP trials

Springer Medicine

The effect of the MR pulse sequence on the regional corpus callosum morphometry

Abstract

Background and purposes

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background and purposes

Materials and methods

Results

Conclusion

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