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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2019

Open Access 01-12-2019 | Obesity | Review

Association between abdominal obesity and asthma: a meta-analysis

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2019

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Abstract

Background

Studies evaluating the association between abdominal obesity and asthma yielded conflict results. Whether abdominal obesity is positively associated with asthma remains unclear.

Objective

To quantitatively determine the association between abdominal obesity and asthma.

Methods

Databases including PubMed, Web of Science, China National Knowledge Infrastructure, China Biology Medicine disc, Chinese Scientific and Technological Journal Database and Wanfang Data were searched up to February 2018 to collect all relevant studies. Reference lists of related articles were also checked. After study selection and data extraction, meta-analysis was conducted to calculate the pooled odds ratio (OR) and corresponding 95% confidence interval (CI). Subgroup analyses by study design and age groups of participants were further performed. Publication bias was assessed via Begg’s rank correlation and Egger’s linear regression methods.

Results

A total of 13 studies were included in the final meta-analysis, including 2 case–control studies, 6 cohort studies, and 5 cross-sectional studies. Our meta-analysis observed a positive association between abdominal obesity and asthma (OR = 1.47, 95% CI 1.35–1.59). No evidence of heterogeneity (I2 = 10.7%) or publication bias (Begg’s test P = 0.200, Egger’s test P = 0.146) was found. Subgroup analyses by study design and age groups of participants obtained consistently positive results across subgroups. Moreover, our meta-analysis observed similar results when considering this association separately in males and females (Males: OR = 1.37, 95% CI 1.18–1.58; Females: OR = 1.39, 95% CI 1.22–1.58). In addition, the association between abdominal overweight and asthma was further explored in this meta-analysis and the pooled OR and 95% CI was 1.13 (1.03, 1.24), indicating that there is a dose–response relationship between abdominal weight status and asthma.

Conclusions

Our meta-analysis shows a positive association between abdominal obesity and asthma. Moreover, this association is similar in males and females. In addition, our meta-analysis indicates that there is a dose–response relationship between abdominal weight status and asthma. Therefore, addressing abdominal obesity issue is of great importance. More studies are needed in the future to clarify the association between abdominal obesity and asthma.
Literature
1.
Soriano JB, Abajobir AA, Abate KH, Abera SF, Agrawal A, Ahmed MB, et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med. 2017;5:691–706.CrossRef
2.
Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004;59:469–78.CrossRef
3.
To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health. 2012;12:204.CrossRef
4.
Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545–602.CrossRef
5.
Accordini S, Corsico AG, Braggion M, Gerbase MW, Gislason D, Gulsvik A, et al. The cost of persistent asthma in Europe: an international population-based study in adults. Int Arch Allergy Immunol. 2013;160:93–101.CrossRef
6.
Nurmagambetov T, Kuwahara R, Garbe P. The economic burden of asthma in the United States, 2008–2013. Ann Am Thorac Soc. 2018;15:348–56.CrossRef
7.
Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377:13–27.CrossRef
8.
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, et al. Adiposity and cancer at major anatomical sites: umbrella review of the literature. BMJ. 2017;356:j477.CrossRef
9.
Dixon JB. The effect of obesity on health outcomes. Mol Cell Endocrinol. 2010;316:104–8.CrossRef
10.
Egan KB, Ettinger AS, DeWan AT, Holford TR, Holmen TL, Bracken MB. General, but not abdominal, overweight increases odds of asthma among Norwegian adolescents: the Young-HUNT study. Acta Paediatr. 2014;103:1270–6.CrossRef
11.
Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy. 2010;65:1455–63.CrossRef
12.
Brumpton B, Langhammer A, Romundstad P, Chen Y, Mai XM. General and abdominal obesity and incident asthma in adults: the HUNT study. Eur Respir J. 2013;41:323–9.CrossRef
13.
Von Behren J, Lipsett M, Horn-Ross PL, Delfino RJ, Gilliland F, McConnell R, et al. Obesity, waist size and prevalence of current asthma in the California Teachers Study cohort. Thorax. 2009;64:889–93.CrossRef
14.
Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma. Am J Resp Crit Care. 2007;175:661–6.CrossRef
15.
Flaherman V. A meta-analysis of the effect of high weight on asthma. Arch Dis Child. 2006;91:334–9.CrossRef
16.
Azizpour Y, Delpisheh A, Montazeri Z, Sayehmiri K, Darabi B. Effect of childhood BMI on asthma: a systematic review and meta-analysis of case-control studies. BMC Pediatr. 2018;18:143.CrossRef
17.
Chen YC, Dong GH, Lin KC, Lee YL. Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. Obes Rev. 2013;14:222–31.CrossRef
18.
Daniels SR, Khoury PR, Morrison JA. The utility of body mass index as a measure of body fatness in children and adolescents: differences by race and gender. Pediatrics. 1997;99:804–7.CrossRef
19.
Tchernof A, Després J. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93:359–404.CrossRef
20.
Ashwell M, Gunn P, Gibson S. Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev. 2012;13:275–86.CrossRef
21.
Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005;366:1640–9.CrossRef
22.
Wang Y, Rimm EB, Stampfer MJ, Willett WC, Hu FB. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr. 2005;81:555–63.CrossRef
23.
Papoutsakis C, Chondronikola M, Antonogeorgos G, Papadakou E, Matziou V, Drakouli M, et al. Associations between central obesity and asthma in children and adolescents: a case-control study. J Asthma. 2015;52:128–34.CrossRef
24.
Benedetti FJ, Bosa VL, Mariante Giesta J, Fischer GB. Anthropometric indicators of general and central obesity in the prediction of asthma in adolescents, Central obesity in asthma. Nutr Hosp. 2015;32:2540–8.
25.
Appleton SL, Adams RJ, Wilson DH, Taylor AW, Ruffin RE. Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. J Allergy Clin Immunol. 2006;118:1284–91.CrossRef
26.
Turley M, Tobias M, Paul S. Non-fatal disease burden associated with excess body mass index and waist circumference in New Zealand adults. Aust N Z J Public Health. 2006;30:231–7.CrossRef
27.
Chen Y, Rennie D, Cormier Y, Dosman J. Sex specificity of asthma associated with objectively measured body mass index and waist circumference—the Humboldt study. Chest. 2005;128:3048–54.CrossRef
28.
Egan KB, Ettinger AS, DeWan AT, Holford TR, Holmen TL, Bracken MB. Longitudinal associations between asthma and general and abdominal weight status among Norwegian adolescents and young adults: the HUNT Study. Pediatr Obes. 2015;10:345–52.CrossRef
29.
Kronander UN, Falkenberg M, Zetterstrom O. Prevalence and incidence of asthma related to waist circumference and BMI in a Swedish community sample. Resp Med. 2004;98:1108–16.CrossRef
30.
31.
32.
Musaad SMA, Patterson T, Ericksen M, Lindsey M, Dietrich K, Succop P, et al. Comparison of anthropometric measures of obesity in childhood allergic asthma: central obesity is most relevant. J Allergy Clin Immunol. 2009;123:1321–7.CrossRef
33.
Leone N, Courbon D, Berr C, Barberger-Gateau P, Tzourio C, Alperovitch A, et al. Abdominal obesity and late-onset asthma: cross-sectional and longitudinal results: the 3C study. Obesity. 2012;20:628–35.CrossRef
34.
Chen YC, Tu YK, Huang KC, Chen PC, Chu DC, Lee YL. Pathway from central obesity to childhood asthma. Physical fitness and sedentary time are leading factors. Am J Respir Crit Care Med. 2014;189:1194–203.CrossRef
35.
Brumpton BM, Camargo CJ, Romundstad PR, Langhammer A, Chen Y, Mai XM. Metabolic syndrome and incidence of asthma in adults: the HUNT study. Eur Respir J. 2013;42:1495–502.CrossRef
36.
Capelo AV, de Fonseca VM, Peixoto MV, de Carvalho SR, Guerino LG. Central obesity and other factors associated with uncontrolled asthma in women. Allergy Asthma Clin Immunol. 2015;11:12.CrossRef
37.
Vatrella A, Calabrese C, Mattiello A, Panico C, Costigliola A, Chiodini P, et al. Abdominal adiposity is an early marker of pulmonary function impairment: findings from a Mediterranean Italian female cohort. Nutr Metab Cardiovasc Dis. 2016;26:643–8.CrossRef
38.
Van Leeuwen JC, Hoogstrate M, Duiverman EJ, Thio BJ. Effects of dietary induced weight loss on exercise-induced bronchoconstriction in overweight and obese children. Pediatr Pulmonol. 2014;49:1155–61.CrossRef
39.
Dias-Junior SA, Reis M, de Carvalho-Pinto RM, Stelmach R, Halpern A, Cukier A. Effects of weight loss on asthma control in obese patients with severe asthma. Eur Respir J. 2014;43:1368–77.CrossRef
40.
Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy. 2013;43:775–84.CrossRef
41.
Juel CT, Ali Z, Nilas L, Ulrik CS. Asthma and obesity: does weight loss improve asthma control? a systematic review. J Asthma Allergy. 2012;5:21–6.PubMedPubMedCentral
42.
Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma. Am J Respir Crit Care Med. 2006;174:112–9.CrossRef
43.
Fredberg JJ, Inouye D, Miller B, Nathan M, Jafari S, Raboudi SH, et al. Airway smooth muscle, tidal stretches, and dynamically determined contractile states. Am J Respir Crit Care Med. 1997;156:1752–9.CrossRef
44.
Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol. 2008;121:1087–93.CrossRef
45.
Tantisira KG, Weiss ST. Complex interactions in complex traits: obesity and asthma. Thorax. 2001;56(Suppl 2):ii64–73.PubMedPubMedCentral
46.
Lessard A, Almeras N, Turcotte H, Tremblay A, Despres JP, Boulet LP. Adiposity and pulmonary function: relationship with body fat distribution and systemic inflammation. Clin Invest Med. 2011;34:E64–70.CrossRef
47.
Hallstrand TS, Fischer ME, Wurfel MM, Afari N, Buchwald D, Goldberg J. Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol. 2005;116:1235–41.CrossRef
48.
Szczepankiewicz A, Bręborowicz A, Sobkowiak P, Popiel A. Are genes associated with energy metabolism important in asthma and BMI? J Asthma. 2009;46:53–8.CrossRef
49.
Toren K, Brisman J, Jarvholm B. Asthma and asthma-like symptoms in adults assessed by questionnaires. Chest. 1993;104:600–8.CrossRef
50.
De Marco R, Cerveri I, Bugiani M, Ferrari M, Verlato G. An undetected burden of asthma in Italy: the relationship between clinical and epidemiological diagnosis of asthma. Eur Respir J. 1998;11:599–605.PubMed
51.
Braun-Fahrlander C, Gassner M, Grize L, Minder CE, Varonier HS, Vuille JC, et al. Comparison of responses to an asthma symptom questionnaire (ISAAC core questions) completed by adolescents and their parents. Pediatr Pulmonol. 1998;25:159–66.CrossRef
Metadata
Title
Association between abdominal obesity and asthma: a meta-analysis
Publication date
01-12-2019
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2019
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/s13223-019-0333-6

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