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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2018

Open Access 01-12-2018 | Research

Serum periostin levels following small bone fractures, long bone fractures and joint replacements: an observational study

Authors: Rachel Varughese, Ruth Semprini, Claire Munro, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene Braithwaite

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2018

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Abstract

Background

In asthma, serum periostin may potentially be used as a biomarker in the management of patients with Type-2 eosinophilic airway inflammation. However, serum periostin may be influenced by factors other than Type 2 inflammation, potentially confounding its interpretation. We aimed to measure change in periostin following bone injury.

Methods

102 adults without asthma were recruited into three groups: joint replacement surgery, long bone fracture, short bone fracture. Participants underwent seven measurements of serum periostin over 26 weeks after bone injury, and prior to surgery in the joint replacement group. Differences in periostin were measured using a ratio of geometric mean (RGM), with comparison made with pre-surgery (joint replacement) or 26 week (long and short fracture) reference measurements.

Results

In the joint replacement group, periostin fell within 48 h (RGM 0.80, 95% CI 0.75–0.86), then increased to a maximum at 8 weeks (RGM 1.89, 1.77–2.02) and by 26 weeks remained above the reference measurement (RGM 1.27, 1.19–1.36). In the long bone fracture group, periostin was reduced at 48 h (RGM 0.76, 0.71–0.83) and then progressively increased to a maximum at 8 weeks (RGM 1.15, 1.06–1.23) compared with the reference measurement. In the short bone fracture group, periostin was reduced at 48 h (RGM 0.9, 0.85–0.95) but was not different from after week 1 compared with the reference measurement.

Conclusions

Serum periostin levels are influenced by bone injury. The timing and extent of bone injury needs consideration if periostin is used as a biomarker in the management of eosinophilic asthma.
Trial registration This trial was prospectively registered with the Australia New Zealand Trials Registry on Feb 7 2014, (ACTRN12614000151639: https://​www.​anzctr.​org.​au/​Trial/​Registration/​TrialReview.​aspx?​id=​363881).
Appendix
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Metadata
Title
Serum periostin levels following small bone fractures, long bone fractures and joint replacements: an observational study
Authors
Rachel Varughese
Ruth Semprini
Claire Munro
James Fingleton
Cecile Holweg
Mark Weatherall
Richard Beasley
Irene Braithwaite
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2018
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/s13223-018-0254-9

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