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Allergy, Asthma & Clinical Immunology

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Open Access 01-12-2016 | Case report

Polyethylene glycol as a cause of anaphylaxis

Authors: Katharina Wylon, Sabine Dölle, Margitta Worm

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2016

Abstract

Background

Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food.

Case report

We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to identify the trigger of anaphylaxis. In the present case hypersensitivity to the additive polyethylene glycol was confirmed by an IDT suggesting an Immunoglobulin E-dependent mechanism as a cause of the reaction.

Conclusion

Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be underdiagnosed. Cases of immediate-type PEG hypersensitivity were reported with increasing frequency. The awareness regarding the allergenic potential of PEG should be raised and a proper product labelling is crucial to prevent PEG mediated hypersensitivity.

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Title: Polyethylene glycol as a cause of anaphylaxis
Authors: Katharina Wylon
Sabine Dölle
Margitta Worm
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Allergy, Asthma & Clinical Immunology / Issue 1/2016
Electronic ISSN: 1710-1492
DOI: https://doi.org/10.1186/s13223-016-0172-7

At a glance: The STEP trials

Springer Medicine

Polyethylene glycol as a cause of anaphylaxis

Abstract

Background

Case report

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case report

Conclusion

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