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Open Access 01-12-2016 | Letter to the Editor

Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation

Authors: Girish Vitalpur, Ann Esquivel, Kirsten M. Kloepfer, James E. Slaven, Frederick E. Leickly

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2016

Abstract

In this study, we assessed whether multisystem reactions to egg and extensively-heated (EH) egg during OFCs were associated with a history of multisystem reactions. Records of children, who underwent OFC to egg or EH egg over a five-year period were reviewed. Of the 120 challenges, 26 (21.67 %) failed, with 38.4 % (10/26) having multisystem reactions. Of the 13 who had multisystem reactions on initial presentation, only two (15.4 %) had a similar OFC outcome. Eighty percent (8/10) of those who had a multisystem OFC reaction had a less severe initial presentation. Initial and OFC multisystem reactions were not associated with each other.

Sicherer SH. Epidemiology of food allergy. J Allergy Clin Immunol. 2011;127:594–602.CrossRefPubMed

Lemon-Mule H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol. 2008;122:977–83.CrossRefPubMed

Lieberman JA, Huang FR, Sampson HA, Nowak-Wegrzyn A. Outcomes of 100 consecutive open, baked-egg oral food challenges in the allergy office. J Allergy Clin Immunol. 2012;129:1682–4.CrossRefPubMed

Sicherer SH, Wood RA, Vickery BP, et al. The natural history of egg allergy in an observational cohort. J Allergy Clin Immunol. 2014;133:492–9.CrossRefPubMedPubMedCentral

Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol. 1997;100:444–51.CrossRefPubMed

Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS. Work group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123(6 Suppl):S365–83 (Epub 2009/06/16).CrossRefPubMed

Bock SA, Sampson HA, Atkins FM, et al. Double-blind, placebo-controlled food challenge (DBPCFC)as an office procedure: a manual. J Allergy Clin Immunol. 1988;82:986–97.CrossRefPubMed

Clark A, Islam S, King Y, et al. A longitudinal study of resolution of allergy to well-cooked and uncooked egg. Clin Exp Allergy. 2011;41:706–12.CrossRefPubMed

Turner PJ, Mehr S, Joshi P, et al. Safety of food challenges to extensively-heated egg in egg-allergic children: a prospective cohort study. Pediatr Allergy Immunol. 2013;24:450–5.CrossRefPubMed

Title: Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation
Authors: Girish Vitalpur
Ann Esquivel
Kirsten M. Kloepfer
James E. Slaven
Frederick E. Leickly
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Allergy, Asthma & Clinical Immunology / Issue 1/2016
Electronic ISSN: 1710-1492
DOI: https://doi.org/10.1186/s13223-016-0125-1

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Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation

Abstract

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Abstract

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