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Published in: Alzheimer's Research & Therapy 1/2018

Open Access 01-12-2018 | Research

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results

Authors: Rosalinde E. R. Slot, Sander C. J. Verfaillie, Jozefien M. Overbeek, Tessa Timmers, Linda M. P. Wesselman, Charlotte E. Teunissen, Annemiek Dols, Femke H. Bouwman, Niels D. Prins, Frederik Barkhof, Adriaan A. Lammertsma, Bart N. M. Van Berckel, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. Van der Flier

Published in: Alzheimer's Research & Therapy | Issue 1/2018

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Abstract

Background

We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, to cross-sectionally describe participant characteristics, and to evaluate the SCD-plus criteria.

Methods

The SCIENCe is a prospective cohort study of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection and optional amyloid positron emission tomography scan, with annual follow-up. The primary outcome measure is clinical progression.

Results

Cross-sectional evaluation of the first 151 participants (age 64 ± 8, 44% female, Mini-Mental State Examination 29 ± 2) showed that 28 (25%) had preclinical Alzheimer’s disease (AD) (amyloid status available n = 114 (75%)), 58 (38%) had subthreshold psychiatry, and 65 (43%) had neither. More severe subjective complaints were associated with worse objective performance. The SCD-plus criteria age ≥ 60 (OR 7.7 (95% CI 1.7–38.9)) and apolipoprotein E (genotype) e4 (OR 4.8 (95% CI 1.6–15.0)) were associated with preclinical AD.

Conclusions

The SCIENCe study confirms that SCD is a heterogeneous group, with preclinical AD and subthreshold psychiatric features. We found a number of SCD-plus criteria to be associated with preclinical AD. Further inclusion and follow-up will address important questions related to SCD.
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Metadata
Title
Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results
Authors
Rosalinde E. R. Slot
Sander C. J. Verfaillie
Jozefien M. Overbeek
Tessa Timmers
Linda M. P. Wesselman
Charlotte E. Teunissen
Annemiek Dols
Femke H. Bouwman
Niels D. Prins
Frederik Barkhof
Adriaan A. Lammertsma
Bart N. M. Van Berckel
Philip Scheltens
Sietske A. M. Sikkes
Wiesje M. Van der Flier
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Alzheimer's Research & Therapy / Issue 1/2018
Electronic ISSN: 1758-9193
DOI
https://doi.org/10.1186/s13195-018-0390-y

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