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Open Access 01-12-2016 | Short report

Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor

Authors: Andreia Latanza Gomes Mathez, Debora Moroto, Sergio Atala Dib, Joao Roberto de Sa

Published in: Diabetology & Metabolic Syndrome | Issue 1/2016

Abstract

A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. This report describes a case of a patient with hypoinsulinemic hypoglycemia and Leser-Trélat sign associated with a malignant solitary fibrous tumor with IGF2 secretion. Both conditions have improved after tumor excision.

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Title: Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor
Authors: Andreia Latanza Gomes Mathez
Debora Moroto
Sergio Atala Dib
Joao Roberto de Sa
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Diabetology & Metabolic Syndrome / Issue 1/2016
Electronic ISSN: 1758-5996
DOI: https://doi.org/10.1186/s13098-016-0148-2

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