Myocellular characteristics in rheumatoid arthritis and osteoarthritis patients

Excerpt

Duijnisveld et al. have published an interesting study on the regenerative potential of muscle satellite cells in chronic inflammation in this journal [1]. They showed that muscle stem cell populations obtained from M. vastus medialis of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) exhibited similar myogenic purity, viability, growth speed, differentiation, and maximum proliferative capacity. Based on these findings in vitro, the authors hypothesized that circulating inflammatory factors in RA negatively influence the regenerative potential of satellite cells and muscle strength in vivo. We aimed to verify whether these results obtained from vastus medialis muscles also apply to a muscle typically involved in the disease process of RA, namely M. interosseus dorsalis manus 1. …