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Open Access 01-12-2017 | Research article

Development of three-dimensional prints of arthritic joints for supporting patients’ awareness to structural damage

Authors: Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett, Axel J. Hueber

Published in: Arthritis Research & Therapy | Issue 1/2017

Abstract

Background

Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in severe joint destruction and functional disability if left untreated. We aim to develop tools that help patients with RA and PsA to understand and experience the impact of inflammatory joint disease on the integrity of their (juxta-articular) bone and increase adherence to medical treatment. In this study, we used high-resolution peripheral quantitative computed tomography (HR-pQCT) to develop 3D prototypes of patients’ finger joints.

Methods

HR-pQCT (XtremeCT, Scanco) measurements were performed in healthy individuals and patients with inflammatory joint disease, followed by a 3D print using the objet30 printer. Healthy participants (n = 10), and patients (n = 15 with RA and 15 with PsA) underwent a detailed, standardized interview with demonstration of printed joints.

Results

Utilizing HR-pQCT images of metacarpophalangeal (MCP) heads, high quality and exact 3D prints as prototypes were created. Erosions in different sizes and the trabecular network printed in detail were visualized, demonstrating structural reduction in arthritic vs. healthy bone. After demonstration of 3D prints (healthy vs. erosive joint, visual and haptic) 26/39 (66%) participants (including healthy volunteers) were deeply affected, often quoting “shock”. Of the patients with RA and PsA, 13/15 (86%) and 11/15 (73%), respectively, stated that they would rethink their attitude to medication adherence. More importantly, 21/24 patients with RA or PsA (87.5%) expressed that they would have wished to see such 3D prints during their first disease-specific conversations.

Conclusion

Using arthro-haptic 3D printed prototypes of joints may help to better understand the impact of inflammatory arthritides on bone integrity and long-term damage.

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Title: Development of three-dimensional prints of arthritic joints for supporting patients’ awareness to structural damage
Authors: Arnd Kleyer
Laura Beyer
Christoph Simon
Fabian Stemmler
Matthias Englbrecht
Christian Beyer
Jürgen Rech
Bernhard Manger
Gerhard Krönke
Georg Schett
Axel J. Hueber
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 1/2017
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/s13075-017-1234-z

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