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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2015

Open Access 01-12-2015 | Editorial

Cross-talk between bone morphogenetic proteins and inflammatory pathways

Authors: Peter M. van der Kraan, Esmeralda N. Blaney Davidson

Published in: Arthritis Research & Therapy | Issue 1/2015

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Abstract

Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and developmental biology. Varas and colleagues report that these factors show cross-talk in rheumatoid arthritis synoviocytes. They show that pro-inflammatory cytokines not only stimulate the production of bone morphogenetic proteins but that these endogenously produced bone morphogenetic proteins interfere with the effects of pro-inflammatory cytokines on synoviocytes.
Literature
1.
Varas A, Valencia J, Lavocat F, Martínez VG, Thiam NN, Hidalgo L, et al. Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes. Arthritis Res Ther. 2015;17:192.PubMedCentralCrossRefPubMed
2.
Brennan FM, Maini RN, Feldmann M. TNF alpha—a pivotal role in rheumatoid arthritis? Br J Rheumatol. 1992;31:293–8.CrossRefPubMed
3.
van den Berg WB, Miossec P. IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol. 2009;5:549–53.CrossRefPubMed
4.
Roeleveld DM, Koenders MI. The role of the Th17 cytokines IL-17 and IL-22 in rheumatoid arthritis pathogenesis and developments in cytokine immunotherapy. Cytokine. 2015;74:101–7.CrossRefPubMed
5.
Bier E, De Robertis EM. BMP gradients: a paradigm for morphogen-mediated developmental patterning. Science. 2015;348:aaa5838.CrossRefPubMed
6.
Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, et al. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science. 2015;348:aaa6071.CrossRefPubMed
7.
Nishinakamura R, Sakaguchi M. BMP signaling and its modifiers in kidney development. Pediatric Nephrol. 2014;29:681–6.CrossRef
8.
Lories RJ, Derese I, Ceuppens JL, Luyten FP. Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum. 2003;48:2807–18.CrossRefPubMed
9.
Fukui N, Zhu Y, Maloney WJ, Clohisy J, Sandell LJ. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am. 2003;85-A Suppl 3:59–66.PubMed
10.
Rifas L. T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization. J Cell Biochem. 2006;98:706–14.CrossRefPubMed
Metadata
Title
Cross-talk between bone morphogenetic proteins and inflammatory pathways
Authors
Peter M. van der Kraan
Esmeralda N. Blaney Davidson
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2015
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-015-0817-9

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