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Trials
Published in: Trials 1/2017

Open Access 01-12-2017 | Review

Developing a core outcome set for chronic rhinosinusitis: a systematic review of outcomes utilised in the current literature

Authors: Archana Soni-Jaiswal, Raj Lakhani, Claire Hopkins

Published in: Trials | Issue 1/2017

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Abstract

Background

A core outcome set (COS) is an agreed standardised collection of outcomes that should be measured and reported by all trials for a specific clinical area, in this case chronic rhinosinusitis. These are not restrictive and researchers may continue to explore other outcomes alongside these that they feel are relevant to their intervention. The aim of this systematic review was to identify the need for a COS for chronic rhinosinusitis.

Methods

A sensitive search strategy was used to identify all published Cochrane systematic reviews and randomised control trials of intervention for adult patients with chronic rhinosinusitis. Two independent authors reviewed these to obtain a list of outcomes and outcome measures reported by each clinical trial.

Results

Sixty-nine randomised control trials and eight Cochrane systematic reviews were included in this study. They reported 68 individual outcomes and outcome measures, with an average of four to ten outcomes per clinical trial. These outcomes were mapped to 23 subcategories belonging to eight core categories.

Conclusions

The key finding of this review was the heterogeneity of outcomes reported and measured by clinical trials of patients with chronic rhinosinusitis, precluding meaningful meta-analysis of data. This review supports the need for development of a COS, to be used in future trials on adult patients with chronic rhinosinusitis.
Literature
1.
Fokkens WJLV, Mullol J, Bachert C, Alobid I, Barody F, et al. European position paper on rhinosinusitis and nasal polyps. Rhinology. 2012;50 Suppl 23:1–298.PubMed
2.
Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A, et al. Chronic rhinosinusitis in Europe—an underestimated disease. A GA(2) LEN study. Allergy. 2011;66(9):1216–23.CrossRefPubMed
3.
Caulley L, Thavorn K, Rudmik L, Cameron C, Kilty SJ. Direct costs of adult chronic rhinosinusitis by using 4 methods of estimation: results of the US Medical Expenditure Panel Survey. J Allergy Clin Immunol. 2015;136(6):1517–22.CrossRefPubMed
4.
Smith KV, Orlandi RR, Rudmik L. Cost of adult chronic rhinosinusitis: a systematic review. Laryngoscopy. 2015;125(7):1547–56.CrossRef
5.
Gliklich RE, Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg. 1995;113(1):104–9.CrossRefPubMed
6.
Chong LY, Head K, Hopkins C, Philpott C, Glew S, Scadding G, et al. Saline irrigation for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4:Cd011995.PubMed
7.
Chong LY, Head K, Hopkins C, Philpott C, Schilder AG, Burton MJ. Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4:Cd011996.PubMed
8.
Chong LY, Head K, Hopkins C, Philpott C, Burton MJ, Schilder AG. Different types of intranasal steroids for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4:Cd011993.PubMed
9.
Head K, Chong LY, Hopkins C, Philpott C, Schilder AG, Burton MJ. Short-course oral steroids as an adjunct therapy for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4.
10.
Head K, Chong LY, Piromchai P, Hopkins C, Philpott C, Schilder AG, et al. Systemic and topical antibiotics for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4:Cd011994.PubMed
11.
12.
Williamson PR, Altman D, Blazeby J, Clarke M, Devane D, Gargon E, et al. Developing core outcome sets for clinical trials: issues to consider. Trials. 2012;13:132.CrossRefPubMedPubMedCentral
13.
14.
Rosenbaum SE, Glenton C, Nylund HK, Oxman AD. Summary-of-findings tables in key information. J Clin Epidemiol. 2010;63:620–6.CrossRefPubMed
15.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.CrossRefPubMedPubMedCentral
16.
17.
Hopkins C, Philpott C, Crowe S, Regan S, Degun A, Papachristou I, et al. Identifying the most important outcomes for systematic reviews of interventions for rhinosinusitis in adults: working with Patients, Public and Practitioners. Rhinology. 2016;54(1):20–6.PubMed
18.
Boers M, Kirwan JR, Gossec L, Philip GC, D’Agostino M, Bingham CO, et al. How to choose core outcome measurement sets for clinical trials: OMERACT II Approves Filter 2.0. J Rheumatol. 2014;41:1025–30.CrossRefPubMed
19.
Sinha IP, Smyth RL, Williamson PR. Using the Delphi Technique to determine which outcomes to measure in clinical trials: recommendations for the future based on a systematic review of existing studies. PLoS Med. 2011;8(1), e1000393.CrossRefPubMedPubMedCentral
20.
Rimmer J, Fokkens W, Chong LY, Hopkins C. Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps. Cochrane Database Syst Rev. 2014;12, CD006991.
21.
Khalil HS, Nunez DA. Functional endoscopic sinus surgery for chronic rhinosinusitis. Cochrane Database Syst Rev. 2006;3, CD004458.
22.
Harvey R, Hannah SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;3:CD006394.
23.
Piromchai P, Thanaviratananich S, Laopaidboon M. Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults. Cochrane Database Syst Rev. 2011;5:CD008233.
24.
Sacks PL, Harvey RJ, Rimmer J, Gallagher RM, Sacks R. Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis. Cochrane Database Syst Rev. 2011;8, CD008263.
25.
Snidvongs K, Kalish L, Sacks R, Craig JC, Harvey RJ. Topical steroid for chronic rhinosinusitis without polyps. Cochrane Database Syst Rev. 2011;8:CD009274.
26.
Ahmed J, Pal S, Hopkins C, Jayaraj S. Functional endoscopic balloon dilation of sinus ostia for chronic rhinosinusitis. Cochrane Database Syst Rev. 2011;7, CD008515.
27.
Kalish L, Snidvongs K, Sivasubramaniam R, Cope D, Harvey RJ. Topical steroids for nasal polyps. Cochrane Database Syst Rev. 2012;12, CD006549.PubMed
28.
Huang Z, Hwang P, Sun Y, Zhou B. Steroid-eluting sinus stents for improving symptoms in chronic rhinosinusitis patients undergoing functional endoscopic sinus surgery (Review). The Cochrane library. 2015;6:CD010436.
29.
Sharma R, Lakhani R, Rimmer J, Hopkins C. Surgical interventions for chronic rhinosinusitis with nasal polyps (review). The Cochrane library. 2014;11:CD006990.
Metadata
Title
Developing a core outcome set for chronic rhinosinusitis: a systematic review of outcomes utilised in the current literature
Authors
Archana Soni-Jaiswal
Raj Lakhani
Claire Hopkins
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Trials / Issue 1/2017
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-017-2060-y

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