Top

Published in:

Open Access 01-12-2017 | Commentary

Clinical trial registries: more international, converging efforts are needed

Authors: Claudia Pansieri, Chiara Pandolfini, Maurizio Bonati

Published in: Trials | Issue 1/2017

Abstract

Clinical trial registries are being increasingly acknowledged worldwide. We searched for possibly trustworthy online registries that are not already included in the International Clinical Trials Registry Platform to evaluate whether other useful trial data sources exist and whether they could potentially be consulted, since the strategy search within this platform has recently been questioned. Fifty-nine registries were initially identified, and 11 of them fit the criteria applied and were analyzed for quality and usability. Four additional, potentially reliable registries were identified that researchers could exploit in order to obtain a more global view of the issue being investigated.

Taichman DB, Backus J, Baethge C, et al. Sharing clinical trial data: a proposal from the International Committee of Medical Journal Editors. PLoS Med. 2016;13(1):e1001950.CrossRefPubMedPubMedCentral

Pansieri C, Pandolfini C, Bonati M. The evolution in registration of clinical trials: a chronicle of the historical calls and current initiatives promoting transparency. Eur J Clin Pharmacol. 2015;71(10):1159–64.CrossRefPubMed

Glanville JM, Duffy S, McCool R, et al. Searching ClinicalTrials.gov and the International Clinical Trials Registry platform to inform systematic reviews: what are the optimal search approaches? J Med Libr Assoc. 2014;102(3):177–83.CrossRefPubMedPubMedCentral

Munch T, Dufka FL, Greene K, et al. RReACT goes global: perils and pitfalls of constructing a global open-access database of registered analgesic clinical trials and trial results. Pain. 2014;155(7):1313–7.CrossRefPubMed

Eichler HG, Abadie E, Breckenridge A, et al. Open clinical trial data for all? A view from regulators. PLoS Med. 2012;9(4):e1001202.CrossRefPubMedPubMedCentral

Zarin DA, Tse T. Sharing individual participant data (IPD) within the context of the trial reporting system (TRS). PLoS Med. 2016;13(1):e1001946.CrossRefPubMedPubMedCentral

Viergever RF, Li K. Trends in global clinical trial registration: an analysis of numbers of registered clinical trials in different parts of the world from 2004 to 2013. BMJ Open. 2015;5(9):e008932

Ghersi D, Pang T. En route to international clinical trial transparency. Lancet. 2008;372(9649):1531–2.CrossRefPubMed

Richter TA. Clinical research: a globalized network. PLoS One. 2014;9(12):e115063.

10.

Siegfried N, Volmink J, Dhansay A. Does South Africa need a national clinical trials support unit? S Afr Med J. 2010;100(8):521–4.

11.

Baudard M, Yavchitz A, Ravaud P, et al. Impact of searching clinical trial registries in systematic reviews of pharmaceutical treatments: methodological systematic review and reanalysis of meta-analyses. BMJ. 2017;356:j448.

Title: Clinical trial registries: more international, converging efforts are needed
Authors: Claudia Pansieri
Chiara Pandolfini
Maurizio Bonati
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Trials / Issue 1/2017
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/s13063-017-1836-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Clinical trial registries: more international, converging efforts are needed

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2017

STOP smoking and alcohol drinking before OPeration for bladder cancer ﻿(the STOP-OP study),﻿ perioperative smoking and alcohol cessation intervention in relation to radical cystectomy: study protocol for a randomised controlled trial

Investigating interventions to increase uptake of HIV testing and linkage into care or prevention for male partners of pregnant women in antenatal clinics in Blantyre, Malawi: study protocol for a cluster randomised trial

Impact of a pharmacist-led medication review on hospital readmission in a pediatric and elderly population: study protocol for a randomized open-label controlled trial

Atopic Dermatitis Anti-IgE Paediatric Trial (ADAPT): the role of anti-IgE in severe paediatric eczema: study protocol for a randomised controlled trial

Transcranial magnetic stimulation for tinnitus: using the Tinnitus Functional Index to predict benefit in a randomized controlled trial

STOP smoking and alcohol drinking before OPeration for bladder cancer (the STOP-OP study), perioperative smoking and alcohol cessation intervention in relation to radical cystectomy: study protocol for a randomised controlled trial