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Trials
Published in: Trials 1/2017

Open Access 01-12-2017 | Study protocol

Effectiveness of deep versus moderate muscle relaxation during laparoscopic donor nephrectomy in enhancing postoperative recovery: study protocol for a randomized controlled study

Authors: Moira H. D. Bruintjes, Andries E. Braat, Albert Dahan, Gert-Jan Scheffer, Luuk B. Hilbrands, Frank C. H. d’Ancona, Rogier A. R. T. Donders, Cornelis J. H. M. van Laarhoven, Michiel C. Warlé

Published in: Trials | Issue 1/2017

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Abstract

Background

Postoperative recovery after live donor nephrectomy is largely determined by the consequences of postoperative pain and analgesia consumptions. The use of deep neuromuscular blockade has been shown to reduce postoperative pain scores after laparoscopic surgery. In this study, we will investigate whether deep neuromuscular blockade also improves the early quality of recovery after live donor nephrectomy.

Methods

The RELAX-study is a phase IV, multicenter, double-blinded, randomized controlled trial, in which 96 patients, scheduled for living donor nephrectomy, will be randomized into two groups: one with deep and one with moderate neuromuscular blockade. Deep neuromuscular blockade is defined as a post-tetanic count of 1–2. Our primary outcome measurement will be the Quality of Recovery-40 questionnaire (overall score) at 24 h after extubation.

Discussion

This study is, to our knowledge, the first randomized study to assess the effectiveness of deep neuromuscular blockade during laparoscopic donor nephrectomy in enhancing postoperative recovery. The study findings may also be applicable for other laparoscopic procedures.

Trial registration

clinicaltrials.gov, NCT02838134. Registered on 29 June 2016.
Appendix
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Metadata
Title
Effectiveness of deep versus moderate muscle relaxation during laparoscopic donor nephrectomy in enhancing postoperative recovery: study protocol for a randomized controlled study
Authors
Moira H. D. Bruintjes
Andries E. Braat
Albert Dahan
Gert-Jan Scheffer
Luuk B. Hilbrands
Frank C. H. d’Ancona
Rogier A. R. T. Donders
Cornelis J. H. M. van Laarhoven
Michiel C. Warlé
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Trials / Issue 1/2017
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-017-1785-y

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