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Breast Cancer Research
Published in: Breast Cancer Research 1/2015

Open Access 01-12-2015 | Review

Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

Authors: Jia-Min B. Pang, Kylie L. Gorringe, Stephen Q. Wong, Alexander Dobrovic, Ian G. Campbell, Stephen B. Fox

Published in: Breast Cancer Research | Issue 1/2015

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Abstract

Ductal carcinoma in situ is a biologically diverse entity. Whereas some lesions are cured by local surgical excision, others recur as in situ disease or progress to invasive carcinoma with subsequent potential for metastatic spread. Reliable prognostic biomarkers are therefore desirable for appropriate clinical management but remain elusive. In common with invasive breast cancer, ductal carcinoma in situ exhibits many genomic changes, predominantly copy number alterations. Although studies have revealed the genomic heterogeneity within individual ductal carcinoma in situ lesions and the association of certain copy number alterations with nuclear grade, none of the genomic changes defined so far is consistently associated with invasive transformation or recurrence risk in pure ductal carcinoma in situ. This article will review the current landscape of genomic alterations in ductal carcinoma in situ and their potential as prognostic biomarkers together with the technologies used to define these.
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Metadata
Title
Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast
Authors
Jia-Min B. Pang
Kylie L. Gorringe
Stephen Q. Wong
Alexander Dobrovic
Ian G. Campbell
Stephen B. Fox
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2015
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/s13058-015-0586-z

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