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Published in: Critical Care 1/2021

Open Access 01-12-2021 | SARS-CoV-2 | Review

Emerging SARS-CoV-2 variants of concern and potential intervention approaches

Authors: Jasmin Khateeb, Yuchong Li, Haibo Zhang

Published in: Critical Care | Issue 1/2021

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Abstract

The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.
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Metadata
Title
Emerging SARS-CoV-2 variants of concern and potential intervention approaches
Authors
Jasmin Khateeb
Yuchong Li
Haibo Zhang
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
SARS-CoV-2
Published in
Critical Care / Issue 1/2021
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-021-03662-x

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