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Critical Care
Published in: Critical Care 1/2021

Open Access 01-12-2021 | Septic Shock | Letter

Septic shock, noradrenaline requirements and alpha-2 agonists: Fishing in the right pond?

Authors: Auguste Dargent, Luc Quintin, Jean-Pierre Quenot

Published in: Critical Care | Issue 1/2021

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Excerpt

Bellomo et al. [1] confirm the clinical [2‐4] data showing a reduction in noradrenaline (NA) requirements in the setting of septic shock following administration of an alpha-2 agonist, dexmedetomidine. …
Literature
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2.
Pichot C, Mathern P, Khettab F, Ghignone M, Geloen A, Quintin L. Increased pressor response to noradrenaline during septic shock following clonidine? Anaesth Intensive Care. 2010;38:784–5. PubMed
3.
Leroy S, Aladin L, Laplace C, Jalem S, Rosenthal J, Abrial A, et al. Introduction of a centrally anti-hypertensive, clonidine, reduces noradrenaline requirements in septic shock caused by necrotizing enterocolitis. Am J Emerg Med. 2017;35:e3-377. CrossRef
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6.
Lankadeva YR, Ma S, Iguchi N, et al. Dexmedetomidine reduces norepinephrine requirements and preserves renal oxygenation and function in ovine septic acute kidney injury. Kidney Int. 2019;96:1150–61. CrossRef
7.
Lankadeva YR, Booth LC, Kosaka J, et al. Clonidine restores pressor responsiveness to phenylephrine and angiotensin II in ovine sepsis. Crit Care Med. 2015;43:e221–9. CrossRef
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Morelli A, Sanfilippo F, Arnemann P, et al. The effect of propofol and dexmedetomidine sedation on norepinephrine requirements in septic shock patients: a cross over trial. Crit Care Med. 2019;47:e89-95. CrossRef
9.
Pichot C, Mathern P, Khettab F, et al. Increased pressor response to noradrenaline during septic shock following clonidine. Anaesth Intensive Care. 2010;38:784–5. PubMed
Metadata
Title
Septic shock, noradrenaline requirements and alpha-2 agonists: Fishing in the right pond?
Authors
Auguste Dargent
Luc Quintin
Jean-Pierre Quenot
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2021
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03377-5

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