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Critical Care
Published in: Critical Care 1/2020

01-12-2020 | Bronchial Asthma | Review

A narrative review on trans-nasal pulmonary aerosol delivery

Authors: Jie Li, James B. Fink, Ronan MacLoughlin, Rajiv Dhand

Published in: Critical Care | Issue 1/2020

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Abstract

The use of trans-nasal pulmonary aerosol delivery via high-flow nasal cannula (HFNC) has expanded in recent years. However, various factors influencing aerosol delivery in this setting have not been precisely defined, and no consensus has emerged regarding the optimal techniques for aerosol delivery with HFNC. Based on a comprehensive literature search, we reviewed studies that assessed trans-nasal pulmonary aerosol delivery with HFNC by in vitro experiments, and in vivo, by radiolabeled, pharmacokinetic and pharmacodynamic studies. In these investigations, the type of nebulizer employed and its placement, carrier gas, the relationship between gas flow and patient’s inspiratory flow, aerosol delivery strategies (intermittent unit dose vs continuous administration by infusion pump), and open vs closed mouth breathing influenced aerosol delivery. The objective of this review was to provide rational recommendations for optimizing aerosol delivery with HFNC in various clinical settings.
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Metadata
Title
A narrative review on trans-nasal pulmonary aerosol delivery
Authors
Jie Li
James B. Fink
Ronan MacLoughlin
Rajiv Dhand
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03206-9

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