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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | Infliximab | Research Letter

Infliximab against severe COVID-19-induced cytokine storm syndrome with organ failure—a cautionary case series

Authors: Andreas Stallmach, Andreas Kortgen, Falk Gonnert, Sina M. Coldewey, Philipp Reuken, Michael Bauer

Published in: Critical Care | Issue 1/2020

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Excerpt

The severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic has prompted search for therapeutics tackling both the pathogen and the overwhelming host response, on an unprecedented scale. In a minority of patients, the disease may cause frequently lethal complications from acute respiratory distress syndrome to multisystem organ failure presumably driven by a cytokine storm [1]. Therefore, anti-cytokine therapies may be helpful to prevent tissue injury. However, these anti-inflammatory drugs constitute double-edged swords; while they can prevent organ damage, they increase the risk of concomitant (super)infection. …
Literature
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Neurath MF. Covid-19 and immunomodulation in IBD. Gut. 2020..
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Liu J, Li S, Liu J, Liang B, Wang X, Wang H, et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine. 2020;55:102763.CrossRef
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Metadata
Title
Infliximab against severe COVID-19-induced cytokine storm syndrome with organ failure—a cautionary case series
Authors
Andreas Stallmach
Andreas Kortgen
Falk Gonnert
Sina M. Coldewey
Philipp Reuken
Michael Bauer
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03158-0

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