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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | Insulins | Research Letter

Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19

Authors: Sergey A. Kornilov, Isabelle Lucas, Kathleen Jade, Chengzhen L. Dai, Jennifer C. Lovejoy, Andrew T. Magis

Published in: Critical Care | Issue 1/2020

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Excerpt

To the Editor: …
Literature
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2.
Guo W, LM, Dong Y, et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diab Metab Res Rev. 2020:e3319.
3.
Swärd P, Edsfeldt A, Reepalu A, Jehpsson L, Rosengren BE, Karlsson MK. Age and sex differences in soluble ACE2 may give insights for COVID-19. Crit Care. 2020;24(1):221.CrossRef
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Sama IE, Ravera A, Santema BT, et al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J. 2020;41(19):1810–7.CrossRef
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Zubair N, Conomos M, Hood L, et al. Genetic predisposition impacts clinical changes in a lifestyle coaching program. Sci Rep. 2019;9:6805.CrossRef
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Herath CB, Warner FJ, et al. Upregulation of hepatic Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1–7) levels in experimental biliary fibrosis. J Hepatol. 2007;47(3):387–95.CrossRef
Metadata
Title
Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19
Authors
Sergey A. Kornilov
Isabelle Lucas
Kathleen Jade
Chengzhen L. Dai
Jennifer C. Lovejoy
Andrew T. Magis
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03141-9

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