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Open Access 01-12-2020 | SARS-CoV-2 | Letter

Clarifying the controversial risk-benefit profile of soluble ACE2 in COVID-19

Author: Melvin Khee Shing Leow

Published in: Critical Care | Issue 1/2020

Excerpt

To the Editor: …

Swärd P, Edsfeldt A, Reepalu A, Jehpsson L, Rosengren BE, Karlsson MK. Age and sex differences in soluble ACE2 may give insights for COVID-19. Crit Care. 2020;24(1):221. https://doi.org/10.1186/s13054-020-02942-2.CrossRefPubMedPubMedCentral

Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of the SARS-Cov-2 by full length human ACE-2. Science. 2020;367(6485):1444–8.CrossRef

Patel VB, Clarke N, Wang Z, Fan D, Parajuli N, Basu R, Putko B, Kassiri Z, Turner AJ, Oudit GY. Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS. J Mol Cell Cardiol. 2014;66:167–76.CrossRef

Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005;111(20):2605–10. https://doi.org/10.1161/CIRCULATIONAHA.104.510461.CrossRef

Wang K, Gheblawi M, Oudit GY. Angiotensin converting enzyme 2: a double edged sword. Circulation. 2020. https://doi.org/10.1161/CIRCULATIONAHA.120.047049.

Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region. Italy: JAMA. 2020;323(16):1574–1581. https://doi.org/10.1001/jama.2020.5394.

Title: Clarifying the controversial risk-benefit profile of soluble ACE2 in COVID-19
Author: Melvin Khee Shing Leow
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: SARS-CoV-2
COVID-19
Published in: Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-020-03097-w

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Clarifying the controversial risk-benefit profile of soluble ACE2 in COVID-19

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Keynote webinar | Spotlight on sleep in brain health

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