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Critical Care
Published in: Critical Care 1/2019

Open Access 01-12-2019 | Echocardiography | Research

Myocardial ischemia during ventilator weaning: a prospective multicenter cohort study

Authors: Alexandre Bedet, Françoise Tomberli, Gwenael Prat, Pierre Bailly, Achille Kouatchet, Sater Mortaza, Emmanuel Vivier, Sylvene Rosselli, Larissa Lipskaia, Guillaume Carteaux, Keyvan Razazi, Armand Mekontso Dessap

Published in: Critical Care | Issue 1/2019

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Abstract

Background

Weaning-induced cardiac pulmonary edema (WiPO) is one of the main mechanisms of weaning failure during mechanical ventilation. We hypothesized that weaning-induced cardiac ischemia (WiCI) may contribute to weaning failure from cardiac origin.

Methods

A prospective cohort study of patients mechanically ventilated for at least 24 h who failed a first spontaneous breathing trial (SBT) was conducted in four intensive care units. Patients were explored during a second SBT using multiple tools (echocardiography, continuous 12-lead ST monitoring, biomarkers) to scrutinize the mechanisms of weaning failure. WiPO definition was based on three criteria (echocardiographic signs of increased left atrial pressure, increase in B-type natriuretic peptides, or increase in protein concentration during SBT) according to a conservative definition (at least two criteria) and a liberal definition (at least one criterion). WiCI was diagnosed according to the third universal definition of myocardial infarction proposed by the European Society of Cardiology (ESC) and the American Heart Association (AHA) statement for exercise testing.

Results

Among patients who failed a first SBT, WiPO occurred in 124/208 (59.6%) and 44/208 (21.2%) patients, according to the liberal and conservative definition, respectively. Among patients with ST monitoring, WiCI was diagnosed in 36/177 (20.3%) and 12/177 (6.8%) of them, according to the ESC and AHA definitions, respectively. WiCI was not associated with WiPO and was not associated with weaning outcomes. Only two patients of the cohort were treated for an acute coronary syndrome after the second SBT, and seven other patients required coronary angiography during the weaning period.

Conclusions

This observational study showed the common occurrence of pulmonary edema in mechanically ventilated patients who failed a first SBT, but the association with cardiac ischemia and weaning outcomes was weak.
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Metadata
Title
Myocardial ischemia during ventilator weaning: a prospective multicenter cohort study
Authors
Alexandre Bedet
Françoise Tomberli
Gwenael Prat
Pierre Bailly
Achille Kouatchet
Sater Mortaza
Emmanuel Vivier
Sylvene Rosselli
Larissa Lipskaia
Guillaume Carteaux
Keyvan Razazi
Armand Mekontso Dessap
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2601-8

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