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Critical Care
Published in: Critical Care 1/2019

Open Access 01-12-2019 | Septicemia | Review

Functions and regulation of lipocalin-2 in gut-origin sepsis: a narrative review

Authors: Fanglin Lu, Kei Inoue, Jungo Kato, Shizuka Minamishima, Hiroshi Morisaki

Published in: Critical Care | Issue 1/2019

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Abstract

Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.
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Metadata
Title
Functions and regulation of lipocalin-2 in gut-origin sepsis: a narrative review
Authors
Fanglin Lu
Kei Inoue
Jungo Kato
Shizuka Minamishima
Hiroshi Morisaki
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2550-2

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