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Critical Care
Published in: Critical Care 1/2019

Open Access 01-12-2019 | Antibiotic | Letter

Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department

Authors: Mari Rosenqvist, Darius Cameron Wilson, Lena Tegnér, Maria Bengtsson-Toni, Marjaneh Peyman, Juan Gonzalez del Castillo, Kordo Saeed, Olle Melander

Published in: Critical Care | Issue 1/2019

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Excerpt

Antibiotics are often prescribed in the emergency department (ED) to patients presenting with a suspected infection before any definitive diagnosis can be made [1]. However, increasing antibiotic resistance and detrimental effects on the microbiota require their use to be limited to those with a high likelihood of bacterial infection or the potential for further clinical deterioration. Conversely, withheld or delayed treatment in higher severity patients may lead to increased morbidity and mortality rates [2]. Thus, an accurate assessment of antibiotic requirement and speed of administration is crucial. …
Literature
1.
van der Does Y, Limper M, Jie KE, Schuit SCE, Jansen H, Pernot N, et al. Procalcitonin-guided antibiotic therapy in patients with fever in a general emergency department population: a multicenter noninferiority randomized clinical trial (HiTEMP study). Clin Microbiol Infect. 2018;24(12):1281–9.
2.
Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, et al. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017;376:2235–44.CrossRef
3.
Huang DT, Yealy DM, Filbin MR, Brown AM, Chang CH, Doi Y, et al. Procalcitonin-guided use of antibiotics for lower respiratory tract infection. N Engl J Med. 2018;379:236–49.CrossRef
4.
Saeed K, Wilson DC, Bloos F, Schuetz P, van der Does Y, Melander O, et al. The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study. Crit Care. 2019;23:40.CrossRef
5.
Schuetz P, Beishuizen A, Broyles M, Ferrer R, Gavazzi G, Gluck EH, et al. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clin Chem Lab Med. 2019. https://​doi.​org/​10.​1515/​cclm-20181181 Epub ahead of print.
Metadata
Title
Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department
Authors
Mari Rosenqvist
Darius Cameron Wilson
Lena Tegnér
Maria Bengtsson-Toni
Marjaneh Peyman
Juan Gonzalez del Castillo
Kordo Saeed
Olle Melander
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2422-9

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