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Open Access 01-12-2019 | Septicemia | Letter

Letter on “Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial”

Authors: Alexander Reisinger, Vanessa Stadlbauer

Published in: Critical Care | Issue 1/2019

Excerpt

Recently a very interesting article was published by Shimizu et al. [1] about the use of synbiotic (pro- and prebiotic) therapy in patients with sepsis in the intensive care unit. We were looking forward to this randomized trial, because conclusive and high evidence data is still sparse on this topic in intensive care medicine. However, we believe that the paper has some methodological flaws that impair the validity of the study: …

Shimizu K, Yamada T, Ogura H, et al. Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial. Crit Care. 2018 Sep 27;22(1):239. https://doi.org/10.1186/s13054-018-2167-x.CrossRefPubMedPubMedCentral

Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011. Available from http://handbook.cochrane.org.

Zmora N, Zilberman-Schapira G, Suez J, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell. 2018;174(6):1388–1405.e21. https://doi.org/10.1016/j.cell.2018.08.041.CrossRefPubMed

Yakult Pharmaceutical Industry Co.,Ltd. OLIGOMATE^Ⓡ . https://www.yakult.co.jp/ypi/en/product/ori.html. Accessed 4 Jan 2019.

Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). Crit Care Med. 2016;44(2):390–438.CrossRef

Shimizu K, Ogura H, Asahara T, Nomoto K, Morotomi M, Nakahori Y, et al. Gastrointestinal dysmotility is associated with altered gut flora and septic mortality in patients with severe systemic inflammatory response syndrome: a preliminary study. Neurogastroenterol Motil. 2011;23(4):330–e157.CrossRef

Ojima M, Motooka D, Shimizu K, Gotoh K, Shintani A, Yoshiya K, et al. Metagenomic analysis reveals dynamic changes of whole gut microbiota in the acute phase of intensive care unit patients. Dig Dis Sci. 2015;61(6):1628–34.CrossRef

Shimizu K, Ogura H, Hamasaki T, Goto M, Tasaki O, Asahara T, et al. Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome. Dig Dis Sci. 2011;56(4):1171–7.CrossRef

Title: Letter on “Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial”
Authors: Alexander Reisinger
Vanessa Stadlbauer
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Septicemia
Septicemia
Nutrition
Respiratory Microbiota
Published in: Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-019-2319-7

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Letter on “Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial”

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